ARLY_STRP2
ID ARLY_STRP2 Reviewed; 463 AA.
AC Q04MW6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=SPD_0111;
OS Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=373153;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D39 / NCTC 7466;
RX PubMed=17041037; DOI=10.1128/jb.01148-06;
RA Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT pneumoniae and comparison with that of unencapsulated laboratory strain
RT R6.";
RL J. Bacteriol. 189:38-51(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; CP000410; ABJ55243.1; -; Genomic_DNA.
DR RefSeq; WP_001107614.1; NC_008533.2.
DR AlphaFoldDB; Q04MW6; -.
DR SMR; Q04MW6; -.
DR STRING; 373153.SPD_0111; -.
DR EnsemblBacteria; ABJ55243; ABJ55243; SPD_0111.
DR GeneID; 60233883; -.
DR GeneID; 66805317; -.
DR KEGG; spd:SPD_0111; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_9; -.
DR OMA; KKNPDVF; -.
DR OrthoDB; 751464at2; -.
DR BioCyc; SPNE373153:G1G6V-119-MON; -.
DR UniPathway; UPA00068; UER00114.
DR PHI-base; PHI:4922; -.
DR Proteomes; UP000001452; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT CHAIN 1..463
FT /note="Argininosuccinate lyase"
FT /id="PRO_1000000548"
SQ SEQUENCE 463 AA; 52324 MW; 936BA74D008B5121 CRC64;
MAKNTKLWGG RFEGTVEDWV ERFGASISFD QKLAKFDVIG SLAHVQMLGQ TGILSLEESE
KIQVGLKELL EELEAGQLDF DIANEDIHMN MEVLLTEKIG PLAGKLHTAR SRNDQVATDM
HLYLKEQLGY VLDKLAHLKG VLLDLAENHV ATIMPGYTHL QHAQPISFAY HLMAYYNMFQ
RDSERFEFNQ KHTDLCPLGA AALAGTTFPI DRQLSSDLLE FKQPYTNSLD AVSDRDFILE
FLSNASILMM HMSRFCEEMI NWCSFEYQFI TLSDTFTIGS SIMPQKKNPD MAELIRGKTG
RVYGHLFGLL TVMKSLPLAY NKDLQEDKEG MFDTVETILN SLDVLAGMLS SLQVNKEKMQ
ESTEKDFSNA TELADYLAGK GLPFREAHEV VGRLVLDSIK SAKNLQDWTL EELQTYHSLI
TEDIYVYLQP KTAVQRRNSL GGTGFDQVEY QIAVAKKANE AKK