ID   MMPL5_MYCTO             Reviewed;         964 AA.
AC   P9WJV0; L0T659; O53784;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Siderophore exporter MmpL5 {ECO:0000250|UniProtKB:P9WJV1};
GN   Name=mmpL5; OrderedLocusNames=MT0705;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of an export system, which is required for biosynthesis
CC       and secretion of siderophores. {ECO:0000250|UniProtKB:P9WJV1}.
CC   -!- SUBUNIT: Interacts with MmpS5. {ECO:0000250|UniProtKB:P9WJV1}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WJV1}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44930.1; -; Genomic_DNA.
DR   PIR; E70826; E70826.
DR   RefSeq; WP_003898551.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJV0; -.
DR   EnsemblBacteria; AAK44930; AAK44930; MT0705.
DR   KEGG; mtc:MT0705; -.
DR   PATRIC; fig|83331.31.peg.751; -.
DR   HOGENOM; CLU_005108_3_2_11; -.
DR   PHI-base; PHI:2741; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..964
FT                   /note="Siderophore exporter MmpL5"
FT                   /id="PRO_0000427766"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        773..793
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        803..823
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        826..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        880..900
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        923..943
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   964 AA;  104771 MW;  A1A595940A1176BD CRC64;
     MIVQRTAAPT GSVPPDRHAA RPFIPRMIRT FAVPIILGWL VTIAVLNVTV PQLETVGQIQ
     AVSMSPDAAP SMISMKHIGK VFEEGDSDSA AMIVLEGQRP LGDAAHAFYD QMIGRLQADT
     THVQSLQDFW GDPLTATGAQ SSDGKAAYVQ VKLAGNQGES LANESVEAVK TIVERLAPPP
     GVKVYVTGSA ALVADQQQAG DRSLQVIEAV TFTVIIVMLL LVYRSIITSA IMLTMVVLGL
     LATRGGVAFL GFHRIIGLST FATNLLVVLA IAAATDYAIF LIGRYQEARG LGQDRESAYY
     TMFGGTAHVV LGSGLTIAGA TFCLSFTRLP YFQTLGVPLA IGMVIVVAAA LTLGPAIIAV
     TSRFGKLLEP KRMARVRGWR KVGAAIVRWP GPILVGAVAL ALVGLLTLPG YRTNYNDRNY
     LPADLPANEG YAAAERHFSQ ARMNPEVLMV ESDHDMRNSA DFLVINKIAK AIFAVEGISR
     VQAITRPDGK PIEHTSIPFL ISMQGTSQKL TEKYNQDLTA RMLEQVNDIQ SNIDQMERMH
     SLTQQMADVT HEMVIQMTGM VVDVEELRNH IADFDDFFRP IRSYFYWEKH CYDIPVCWSL
     RSVFDTLDGI DVMTEDINNL LPLMQRLDTL MPQLTAMMPE MIQTMKSMKA QMLSMHSTQE
     GLQDQMAAMQ EDSAAMGEAF DASRNDDSFY LPPEVFDNPD FQRGLEQFLS PDGHAVRFII
     SHEGDPMSQA GIARIAKIKT AAKEAIKGTP LEGSAIYLGG TAAMFKDLSD GNTYDLMIAG
     ISALCLIFII MLITTRSVVA AAVIVGTVVL SLGASFGLSV LIWQHILGIE LHWLVLAMAV
     IILLAVGADY NLLLVARLKE EIHAGINTGI IRAMGGSGSV VTAAGLVFAF TMMSFAVSEL
     TVMAQVGTTI GMGLLFDTLI VRSFMTPSIA ALLGKWFWWP QVVRQRPVPQ PWPSPASART
     FALV