ID   MMPL6_MYCTU             Reviewed;         397 AA.
AC   P9WJU9; L0T707; Q10773;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Probable transport protein MmpL6 {ECO:0000305};
GN   Name=mmpL6; OrderedLocusNames=Rv1557; ORFNames=MTCY48.08c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44321.1; -; Genomic_DNA.
DR   PIR; B70763; B70763.
DR   RefSeq; NP_216073.1; NC_000962.3.
DR   RefSeq; WP_003901197.1; NC_000962.3.
DR   AlphaFoldDB; P9WJU9; -.
DR   STRING; 83332.Rv1557; -.
DR   PaxDb; P9WJU9; -.
DR   GeneID; 886033; -.
DR   KEGG; mtu:Rv1557; -.
DR   PATRIC; fig|83332.111.peg.1734; -.
DR   TubercuList; Rv1557; -.
DR   eggNOG; COG2409; Bacteria.
DR   OMA; FLWADFA; -.
DR   PhylomeDB; P9WJU9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010033; P:response to organic substance; IEP:MTBBASE.
DR   InterPro; IPR004869; MMPL_dom.
DR   Pfam; PF03176; MMPL; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..397
FT                   /note="Probable transport protein MmpL6"
FT                   /id="PRO_0000103569"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   397 AA;  42422 MW;  678DC86E24472BF4 CRC64;
     MQGISVTGLV KRGWMVRSVF DTIDGIDQLG EQLASVTVTL DKLAAIQPQL VALLPDEIAS
     QQINRELALA NYATMSGIYA QTAALIENAA AMGQAFDAAK NDDSFYLPPE AFDNPDFQRG
     LKLFLSADGK AARMIISHEG DPATPEGISH IDAIKQAAHE AVKGTPMAGA GIYLAGTAAT
     FKDIQDGATY DLLIAGIAAL SLILLIMMII TRSLVAALVI VGTVALSLGA SFGLSVLVWQ
     HLLGIQLYWI VLALAVILLL AVGSDYNLLL ISRFKEEIGA GLNTGIIRAM AGTGGVVTAA
     GLVFAATMSS FVFSDLRVLG QIGTTIGLGL LFDTLVVRAF MTPSIAVLLG RWFWWPQRVR
     PRPASRMLRP YGPRPVVREL LLREGNDDPR TQVATHR