ID   MMPL7_MYCBO             Reviewed;         920 AA.
AC   P65371; A0A1R3Y320; P96289; X2BM63;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Probable transport protein MmpL7 {ECO:0000305};
GN   Name=mmpL7; OrderedLocusNames=BQ2027_MB2967;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01588.1; -; Genomic_DNA.
DR   RefSeq; NP_856612.1; NC_002945.3.
DR   RefSeq; WP_003414861.1; NC_002945.4.
DR   AlphaFoldDB; P65371; -.
DR   EnsemblBacteria; SIU01588; SIU01588; BQ2027_MB2967.
DR   PATRIC; fig|233413.5.peg.3256; -.
DR   OMA; VRQSMFS; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   Pfam; PF03176; MMPL; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..920
FT                   /note="Probable transport protein MmpL7"
FT                   /id="PRO_0000103571"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        761..781
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        790..810
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        822..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        864..884
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        888..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   920 AA;  95122 MW;  019FCA9294A854D2 CRC64;
     MPSPAGRLHR IRYIRLKKSS PDCRATITSG SADGQRRSPR LTNLLVVAAW VAAAVIANLL
     LTFTQAEPHD TSPALLPQDA KTAAATSRIA QAFPGTGSNA IAYLVVEGGS TLEPQDQPYY
     DAAVGALRAD TRHVGSVLDW WSDPVTAPLG TSPDGRSATA MVWLRGEAGT TQAAESLDAV
     RSVLRQLPPS EGLRASIVVP AITNDMPMQI TAWQSATIVT VAAVIAVLLL LRARLSVRAA
     AIVLLTADLS LAVAWPLAAV VRGHDWGTDS VFSWTLAAVL TIGTITAATM LAARLGSDAG
     HSAAPTYRDS LPAFALPGAC VAIFTGPLLL ARTPALHGVG TAGLGVFVAL AASLTVLPAL
     IALAGASRQL PAPTTGAGWT GRLSLPVSSA SALGTAAVLA ICMLPIIGMR WGVAENPTRQ
     GGAQVLPGNA LPDVVVIKSA RDLRDPAALI AINQVSHRLV EVPGVRKVES AAWPAGVPWT
     DASLSSAAGR LADQLGQQAG SFVPAVTAIK SMKSIIEQMS GAVDQLDSTV NVTLAGARQA
     QQYLDPMLAA ARNLKNKTTE LSEYLETIHT WIVGFTNCPD DVLCTAMRKV IEPYDIVVTG
     MNELSTGADR ISAISTQTMS ALSSAPRMVA QMRSALAQVR SFVPKLETTI QDAMPQIAQA
     SAMLKNLSAD FADTGEGGFH LSRKDLADPS YRHVRESMFS SDGTATRLFL YSDGQLDLAA
     AARAQQLEIA AGKAMKYGSL VDSQVTVGGA AQIAAAVRDA LIHDAVLLAV ILLTVVALAS
     MWRGAVHGAA VGVGVLASYL AALGVSIALW QHLLDRELNA LVPLVSFAVL ASCGVPYLVA
     GIKAGRIADE ATGARSKGAV SGRGAVAPLA ALGGVFGAGL VLVSGGSFSV LSQIGTVVVL
     GLGVLITVQR AWLPTTPGRR