ID   MMPL7_MYCTO             Reviewed;         920 AA.
AC   P9WJU6; L0TB36; P65370; P96289;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Phthiocerol dimycocerosate exporter MmpL7 {ECO:0000250|UniProtKB:P9WJU7};
GN   Name=mmpL7; OrderedLocusNames=MT3012;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for export of phthiocerol dimycocerosate (PDIM) to
CC       the cell wall. {ECO:0000250|UniProtKB:P9WJU7}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WJU7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47339.1; -; Genomic_DNA.
DR   PIR; C70668; C70668.
DR   RefSeq; WP_003414861.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJU6; -.
DR   EnsemblBacteria; AAK47339; AAK47339; MT3012.
DR   KEGG; mtc:MT3012; -.
DR   PATRIC; fig|83331.31.peg.3253; -.
DR   HOGENOM; CLU_327012_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004869; MMPL_dom.
DR   Pfam; PF03176; MMPL; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cell wall biogenesis/degradation;
KW   Lipid transport; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..920
FT                   /note="Phthiocerol dimycocerosate exporter MmpL7"
FT                   /id="PRO_0000427768"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        761..781
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        790..810
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        822..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        864..884
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        888..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   920 AA;  95122 MW;  019FCA9294A854D2 CRC64;
     MPSPAGRLHR IRYIRLKKSS PDCRATITSG SADGQRRSPR LTNLLVVAAW VAAAVIANLL
     LTFTQAEPHD TSPALLPQDA KTAAATSRIA QAFPGTGSNA IAYLVVEGGS TLEPQDQPYY
     DAAVGALRAD TRHVGSVLDW WSDPVTAPLG TSPDGRSATA MVWLRGEAGT TQAAESLDAV
     RSVLRQLPPS EGLRASIVVP AITNDMPMQI TAWQSATIVT VAAVIAVLLL LRARLSVRAA
     AIVLLTADLS LAVAWPLAAV VRGHDWGTDS VFSWTLAAVL TIGTITAATM LAARLGSDAG
     HSAAPTYRDS LPAFALPGAC VAIFTGPLLL ARTPALHGVG TAGLGVFVAL AASLTVLPAL
     IALAGASRQL PAPTTGAGWT GRLSLPVSSA SALGTAAVLA ICMLPIIGMR WGVAENPTRQ
     GGAQVLPGNA LPDVVVIKSA RDLRDPAALI AINQVSHRLV EVPGVRKVES AAWPAGVPWT
     DASLSSAAGR LADQLGQQAG SFVPAVTAIK SMKSIIEQMS GAVDQLDSTV NVTLAGARQA
     QQYLDPMLAA ARNLKNKTTE LSEYLETIHT WIVGFTNCPD DVLCTAMRKV IEPYDIVVTG
     MNELSTGADR ISAISTQTMS ALSSAPRMVA QMRSALAQVR SFVPKLETTI QDAMPQIAQA
     SAMLKNLSAD FADTGEGGFH LSRKDLADPS YRHVRESMFS SDGTATRLFL YSDGQLDLAA
     AARAQQLEIA AGKAMKYGSL VDSQVTVGGA AQIAAAVRDA LIHDAVLLAV ILLTVVALAS
     MWRGAVHGAA VGVGVLASYL AALGVSIALW QHLLDRELNA LVPLVSFAVL ASCGVPYLVA
     GIKAGRIADE ATGARSKGAV SGRGAVAPLA ALGGVFGAGL VLVSGGSFSV LSQIGTVVVL
     GLGVLITVQR AWLPTTPGRR