ID   MMPL8_MYCBP             Reviewed;        1089 AA.
AC   A1KQF8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Probable transport protein MmpL8 {ECO:0000305};
GN   Name=mmpL8; OrderedLocusNames=BCG_3886c;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- MISCELLANEOUS: In strain BCG, the sulfolipid-1 (SL-1) is not
CC       synthesized.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AM408590; CAL73876.1; -; Genomic_DNA.
DR   RefSeq; WP_003908351.1; NC_008769.1.
DR   AlphaFoldDB; A1KQF8; -.
DR   PRIDE; A1KQF8; -.
DR   KEGG; mbb:BCG_3886c; -.
DR   HOGENOM; CLU_005108_3_2_11; -.
DR   OMA; MAQRVSQ; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1089
FT                   /note="Probable transport protein MmpL8"
FT                   /id="PRO_0000314683"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        874..894
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        898..918
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        930..950
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        973..993
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        996..1016
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1056..1078
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1089 AA;  116069 MW;  8C826AF02ADAD435 CRC64;
     MCDVLMQPVR TPRPSTNLRS KPLRPTGDGG VFPRLGRLIV RRPWVVIAFW VALAGLLAPT
     VPSLDAISQR HPVAILPSDA PVLVSTRQMT AAFREAGLQS VAVVVLSDAK GLGAADERSY
     KELVDALRRD TRDVVMLQDF VTTPPLRELM TSKDNQAWIL PVGLPGDLGS TQSKQAYARV
     ADIVEHQVAG STLTANLTGP AATVADLNLT GQRDRSRIEF AITILLLVIL LIIYRNPITM
     VLPLITIGMS VVVAQRLVAI AGLAGLGIAN QSIIFMSGMM VGAGTDYAVF LISRYHDYLR
     QGADSDQAVK KALTSIGKVI AASAATVAIT FLGMVFTQLG ILKTVGPMLG ISVAVVFFAA
     VTLLPALMVL TGRRGWIAPR RDLTRRFWRS SGVHIVRRPK THLLASALVL VILAGCAGLA
     RYNYDDRKTL PASVESSIGY AALDKHFPSN LIIPEYLFIQ SSTDLRTPKA LADLEQMVQR
     VSQVPGVAMV RGITRPAGRS LEQARTSWQA GEVGSKLDEG SKQIAAHTGD IDKLAGGANL
     MASKLGDVRA QVNRAISTVG GLIDALAYLQ DLLGGNRVLG ELEGAEKLIG SMRALGDTID
     ADASFVANNT EWASPVLGAL DSSPMCTADP ACASARTELQ RLVTARDDGT LAKISELARQ
     LQATRAVQTL AATVSGLRGA LATVIRAMGS LGMSSPGGVR SKINLVNKGV NDLADGSRQL
     AEGVQLLVDQ VKKMGFGLGE ASAFLLAMKD TATTPAMAGF YIPPELLSYA TGESVKAETM
     PSEYRDLLGG LNVDQLKKVA AAFISPDGHS IRYLIQTDLN PFSTAAMDQI DAITAAARGA
     QPNTALADAK VSVVGLPVVL KDTRDYSDHD LRLIIAMTVC IVLLILIVLL RAIVAPLYLI
     GSVIVSYLAA LGIGVIVFQF LLGQEMHWSI PGLTFVILVA VGADYNMLLI SRLREEAVLG
     VRSGVIRTVA STGGVITAAG LIMAASMYGL VFASLGSVVQ GAFVLGTGLL LDTFLVRTVT
     VPAIAVLVGQ ANWWLPSSWR PATWWPLGRR RGRAQRTKRK PLLPKEEEEQ SPPDDDDLIG
     LWLHDGLRL