ID   MMPL9_MYCTU             Reviewed;         962 AA.
AC   P9WJU3; L0TC13; P95235;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Probable transport protein MmpL9 {ECO:0000305};
GN   Name=mmpL9; OrderedLocusNames=Rv2339; ORFNames=MTCY98.08;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45127.1; -; Genomic_DNA.
DR   PIR; D70661; D70661.
DR   RefSeq; NP_216855.1; NC_000962.3.
DR   RefSeq; WP_003899278.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WJU3; -.
DR   STRING; 83332.Rv2339; -.
DR   PaxDb; P9WJU3; -.
DR   DNASU; 888966; -.
DR   GeneID; 888966; -.
DR   KEGG; mtu:Rv2339; -.
DR   TubercuList; Rv2339; -.
DR   eggNOG; COG2409; Bacteria.
DR   OMA; AVIMIML; -.
DR   PhylomeDB; P9WJU3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042783; P:evasion of host immune response; IMP:MTBBASE.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..962
FT                   /note="Probable transport protein MmpL9"
FT                   /id="PRO_0000103573"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        768..788
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        796..816
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        820..840
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        867..887
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        895..915
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   962 AA;  104613 MW;  9CAE3AE4F44AC9E5 CRC64;
     MVPGEVHMSD TPSGPHPIIP RTIRLAAIPI LLCWLGFTVF VSVAVPPLEA IGETRAVAVA
     PDDAQSMRAM RRAGKVFNEF DSNSIAMVVL ESDQPLGEKA HRYYDHLVDT LVLDQSHIQH
     IQDFWRDPLT AAGAVSADGK AAYVQLYLAG NMGEALANES VEAVRKIVAN STPPEGIRTY
     VTGPAALFAD QIAAGDRSMK LITGLTFAVI TVLLLLVYRS IATTLLILPM VFIGLGATRG
     TIAFLGYHGM VGLSTFVVNI LTALAIAAGT DYAIFLVGRY QEARHIGQNR EASFYTMYRG
     TANVILGSGL TIAGATYCLS FARLTLFHTM GPPLAIGMLV SVAAALTLAP AIIAIAGRFG
     LLDPKRRLKT RGWRRVGTAV VRWPGPILAT SVALALVGLL ALPGYRPGYN DRYYLRAGTP
     VNRGYAAADR HFGPARMNPE MLLVESDQDM RNPAGMLVID KIAKEVLHVS GVERVQAITR
     PQGVPLEHAS IPFQISMMGA TQTMSLPYMR ERMADMLTMS DEMLVAINSM EQMLDLVQQL
     NDVTHEMAAT TREIKATTSE LRDHLADIDD FVRPLRSYFY WEHHCFDIPL CSATRSLFDT
     LDGVDTLTDQ LRALTDDMNK MEALTPQFLA LLPPMITTMK TMRTMMLTMR STISGVQDQM
     ADMQDHATAM GQAFDTAKSG DSFYLPPEAF DNAEFQQGMK LFLSPNGKAV RFVISHESDP
     ASTEGIDRIE AIRAATKDAI KATPLQGAKI YIGGTAATYQ DIRDGTKYDI LIVGIAAVCL
     VFIVMLMITQ SLIASLVIVG TVLLSLGTAF GLSVLIWQHF VGLQVHWTIV AMSVIVLLAV
     GSDYNLLLVS RFKEEVGAGL KTGIIRAMAG TGAVVTSAGL VFAFTMASMA VSELRVIGQV
     GTTIGLGLLF DTLVVRSFMT PSIAALLGRW FWWPNMIHSR PTVPEAHTRQ GARRIQPHLH
     RG