MMPLA_MYCLE
ID MMPLA_MYCLE Reviewed; 1008 AA.
AC Q49619; Q9CC63;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable transport protein MmpL10;
GN Name=mmpL10; Synonyms=tp1; OrderedLocusNames=ML1231; ORFNames=B1170_C1_181;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Smith D.R., Robison K.;
RL Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC31612.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U00010; AAA17062.1; -; Genomic_DNA.
DR EMBL; AL583921; CAC31612.1; ALT_INIT; Genomic_DNA.
DR PIR; A87063; A87063.
DR PIR; S72698; S72698.
DR RefSeq; WP_010908213.1; NC_002677.1.
DR AlphaFoldDB; Q49619; -.
DR STRING; 272631.ML1231; -.
DR PRIDE; Q49619; -.
DR EnsemblBacteria; CAC31612; CAC31612; CAC31612.
DR KEGG; mle:ML1231; -.
DR Leproma; ML1231; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_3_0_11; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR Pfam; PF03176; MMPL; 2.
DR TIGRFAMs; TIGR00833; actII; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1008
FT /note="Probable transport protein MmpL10"
FT /id="PRO_0000103576"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 835..855
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 862..882
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 895..915
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 940..960
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 961..981
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1008 AA; 106836 MW; A554907B3ADDF130 CRC64;
MHPGGAIGGE LIFSRLGDIV TRWPWVVIGC WTLLALMLPM TVPSLTELTQ RHPVVILPVD
APSSVAAKKI SQAFHEVDSE NVLIVLLTDD KGLGPADETV YRTLVDRLRN DTKDVVVLQD
FLSTPPLHEL LVSKDGKAWI LPIVLAGELG TSASYQAYAG VAGIVKQTLE STAGSSLKAN
LTGPASTVAD LTDAGARDRT SIELVIAVLL LTILMIIYRN PITMLLPLIT IGASLMTAQA
VVSGVSVLAG LAVSNQMIVL LSAMIAGAGT DYAVFLISRY HDYIRMGSGS AQDAGCAVRQ
ALISLGKVIA ASAATVGITF LGMSFTKIRV FSTVGPALAI GIAVAFLAAV TLMPALLVLA
GTRGWVAPRR DRAGAFWRRT GVRIVRRPVA YLSASMVILI VLALCASLVR FNYDDRKQIP
ASDESSVGYA ALESHFPVGQ AIPEYLLIQS PHDLRTPRAL ADMAELAQRV SQIPGIALVR
GVTRPTGKPL EETSATYQAG MVGKQLGSAS HLIGESTGDL NRLASGAGLL ADKLGDVRIQ
VGQAVAGISG LLDNLAFAQK MFGDSKTLGE IDTAGKLVSS MRALGNMFGI NFSTTMNDIN
WVGAVVIALD SSVLCDTNPI CADARAQFHK LLTASEDGTL DNIAHLWKQL GSTQSSQTIG
ATVSGLEKTL TAVNTSLRSL GLDNPNVMRS KMIGLQNGVN DLASAGRRIA DGVAVLVDQT
RTMGTSLARA SAFLMEMGQD ASQPSMAGFN VPPQLLNTED FKKLVQAFIS PDGHSVRYFI
QTDLNPFSSA AMDQVNTILN VATGAQPNTT LSDASIYLSG YTVTLRDTRD YYDRDLQLIV
IVTMIVVLLI LMALLRSIVA PIYLVGSVIV SYLSALGLCV LVFQVLLRQQ LHWSVPGLAF
VVLVAVGADY NMLLASRLRD ESSHGLRASV IRTVRSTGGV ITAAGLIFAA SMFGLLLSSI
ATVVQAGFVL GSGILLDTFI VRTITVPAVA ALLRRASWWP ARPWGNNA