ID   MMPLA_MYCLE             Reviewed;        1008 AA.
AC   Q49619; Q9CC63;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable transport protein MmpL10;
GN   Name=mmpL10; Synonyms=tp1; OrderedLocusNames=ML1231; ORFNames=B1170_C1_181;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC31612.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U00010; AAA17062.1; -; Genomic_DNA.
DR   EMBL; AL583921; CAC31612.1; ALT_INIT; Genomic_DNA.
DR   PIR; A87063; A87063.
DR   PIR; S72698; S72698.
DR   RefSeq; WP_010908213.1; NC_002677.1.
DR   AlphaFoldDB; Q49619; -.
DR   STRING; 272631.ML1231; -.
DR   PRIDE; Q49619; -.
DR   EnsemblBacteria; CAC31612; CAC31612; CAC31612.
DR   KEGG; mle:ML1231; -.
DR   Leproma; ML1231; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_3_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1008
FT                   /note="Probable transport protein MmpL10"
FT                   /id="PRO_0000103576"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        835..855
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        862..882
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        895..915
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        940..960
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        961..981
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1008 AA;  106836 MW;  A554907B3ADDF130 CRC64;
     MHPGGAIGGE LIFSRLGDIV TRWPWVVIGC WTLLALMLPM TVPSLTELTQ RHPVVILPVD
     APSSVAAKKI SQAFHEVDSE NVLIVLLTDD KGLGPADETV YRTLVDRLRN DTKDVVVLQD
     FLSTPPLHEL LVSKDGKAWI LPIVLAGELG TSASYQAYAG VAGIVKQTLE STAGSSLKAN
     LTGPASTVAD LTDAGARDRT SIELVIAVLL LTILMIIYRN PITMLLPLIT IGASLMTAQA
     VVSGVSVLAG LAVSNQMIVL LSAMIAGAGT DYAVFLISRY HDYIRMGSGS AQDAGCAVRQ
     ALISLGKVIA ASAATVGITF LGMSFTKIRV FSTVGPALAI GIAVAFLAAV TLMPALLVLA
     GTRGWVAPRR DRAGAFWRRT GVRIVRRPVA YLSASMVILI VLALCASLVR FNYDDRKQIP
     ASDESSVGYA ALESHFPVGQ AIPEYLLIQS PHDLRTPRAL ADMAELAQRV SQIPGIALVR
     GVTRPTGKPL EETSATYQAG MVGKQLGSAS HLIGESTGDL NRLASGAGLL ADKLGDVRIQ
     VGQAVAGISG LLDNLAFAQK MFGDSKTLGE IDTAGKLVSS MRALGNMFGI NFSTTMNDIN
     WVGAVVIALD SSVLCDTNPI CADARAQFHK LLTASEDGTL DNIAHLWKQL GSTQSSQTIG
     ATVSGLEKTL TAVNTSLRSL GLDNPNVMRS KMIGLQNGVN DLASAGRRIA DGVAVLVDQT
     RTMGTSLARA SAFLMEMGQD ASQPSMAGFN VPPQLLNTED FKKLVQAFIS PDGHSVRYFI
     QTDLNPFSSA AMDQVNTILN VATGAQPNTT LSDASIYLSG YTVTLRDTRD YYDRDLQLIV
     IVTMIVVLLI LMALLRSIVA PIYLVGSVIV SYLSALGLCV LVFQVLLRQQ LHWSVPGLAF
     VVLVAVGADY NMLLASRLRD ESSHGLRASV IRTVRSTGGV ITAAGLIFAA SMFGLLLSSI
     ATVVQAGFVL GSGILLDTFI VRTITVPAVA ALLRRASWWP ARPWGNNA