ID   MMPLA_STRCO             Reviewed;         711 AA.
AC   Q53902;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Putative membrane protein ActII-3;
GN   Name=actII-3; OrderedLocusNames=SCO5084; ORFNames=SCBAC28G1.10;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1878971; DOI=10.1016/0092-8674(91)90120-n;
RA   Fernandez-Moreno M.A., Caballero J.L., Hopwood D.A., Malpartida F.;
RT   "The act cluster contains regulatory and antibiotic export genes, direct
RT   targets for translational control by the bldA tRNA gene of Streptomyces.";
RL   Cell 66:769-780(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; M64683; AAA26691.1; -; Genomic_DNA.
DR   EMBL; AL939122; CAC44197.1; -; Genomic_DNA.
DR   PIR; C40046; C40046.
DR   RefSeq; NP_629234.1; NC_003888.3.
DR   RefSeq; WP_011030047.1; NZ_VNID01000008.1.
DR   AlphaFoldDB; Q53902; -.
DR   SMR; Q53902; -.
DR   STRING; 100226.SCO5084; -.
DR   TCDB; 2.A.6.5.1; the resistance-nodulation-cell division (rnd) superfamily.
DR   GeneID; 1100525; -.
DR   KEGG; sco:SCO5084; -.
DR   PATRIC; fig|100226.15.peg.5164; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_4_1_11; -.
DR   InParanoid; Q53902; -.
DR   OMA; RHEAMAL; -.
DR   PhylomeDB; Q53902; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF03176; MMPL; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..711
FT                   /note="Putative membrane protein ActII-3"
FT                   /id="PRO_0000103581"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        540..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        573..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        623..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        645..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          685..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  74863 MW;  A5466BEDABEED1B6 CRC64;
     MTRTLLSWPG GRRLKWLVLA AWIGLLIVLQ PLAGKLGDVE SNDAAAWLPG NAESTEVLEL
     SEKFQPADTS PTVIVYDRPS GITAADEAKA RADATHFADG TGVVGEPYGP VRSDDGKALR
     TVVNVHLGKD GWEGLNAAAK DMRAIARPSA PDGLGVHVTG PTGYAADSAE SFSSADFKLT
     LVTLLIVVTI LVVTYRSPLL WLLPMISAGM SLVISQAIVY LLAKNAGLTV NAQTAMILTV
     LVLGAATDYA LLLVARYREE LRRHEDRHEA MAVALRRAGP AIVASAATVA VSMLVLLLAA
     LNSTKGLGPV CAVGVLVGLL SMMTLLPALL VIFGRWVFWP ARPKHGTEPD VTRGLWSRIA
     RLVSGRPRAV WVTTSLLLGA VATLAVTLNA DGLQQKDGFK TKPESVVGEE ILTRHFPAGS
     GEPMVVIAKG ASADQVHAAL ETVPGVIEVA PPQVKDGLAY VEATLGAGAD SPAAMRSVTA
     ARETLARLDG AQARVGGSSA VVHDMREASS RDRGLIIPVI LAVVFCILAL LLRALVAPLL
     LIASVVLSFF TALGLAALFF NHVFDFAGAD SAFPLWVFVF LVALGVDYNI FLVTRIKEES
     DRLGTRQGAL KGLTSTGGVI TAAGLVLAGT FAALATLPLV FIAELGFTVA VGVLLDTMIV
     RSVLVTALTL DVGRWMWWPH PLARREDPSE DPAVSGMPDS IDSEASTTAS R