ID   MMPLB_MYCTO             Reviewed;         966 AA.
AC   P9WJT8; L0T2Z6; O53653; P65374;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Heme uptake protein MmpL11 {ECO:0000250|UniProtKB:P9WJT9};
GN   Name=mmpL11; OrderedLocusNames=MT0212;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of a heme-iron acquisition system. Receives heme from
CC       the heme-binding protein MT0213 and transports it into the
CC       mycobacterial cell. {ECO:0000250|UniProtKB:P9WJT9}.
CC   -!- FUNCTION: Could also transport the mycolic acid-containing lipids
CC       monomeromycolyl diacylglycerol (MMDAG) and mycolate ester wax (WE) to
CC       the bacterial surface. {ECO:0000250|UniProtKB:P9WJT9}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WJT9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK44433.1; -; Genomic_DNA.
DR   PIR; G70838; G70838.
DR   RefSeq; WP_003401190.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJT8; -.
DR   SMR; P9WJT8; -.
DR   EnsemblBacteria; AAK44433; AAK44433; MT0212.
DR   KEGG; mtc:MT0212; -.
DR   PATRIC; fig|83331.31.peg.231; -.
DR   HOGENOM; CLU_005108_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF03176; MMPL; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..966
FT                   /note="Heme uptake protein MmpL11"
FT                   /id="PRO_0000427772"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        557..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        595..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        668..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   966 AA;  103502 MW;  3E8BF0327CBEA2DA CRC64;
     MMRLSRNLRR CRWLVFTGWL LALVPAVYLA MTQSGNLTGG GFEVAGSQSL LVHDQLDAHY
     PDRGAPALAL VAAPRPDASY QDIDNAVALL RQIASELPGV TEAPNPTQRP PQPDRPYVVS
     LRLDARNAGT SDVAKKLRDR IGVKGDQSGQ TANGKVRLYV IGQGALSAAA AANTKHDIAN
     AERWNLPIIL MVLVAVFGSL AAAAIPLALA VCTVVITMGL VFVLSMHTTM SVFVTSTVSM
     FGIALAVDYS LFILMRYREE LRCGRRPPDA VDAAMATSGL AVVLSGMTVI ASLTGIYLIN
     TPALRSMATG AILAVAVAML TSATLTPAVL ATFARAAAKR SALVHWSRRP ASTQSWFWSR
     WVGWVMRRPW ITALAASTVL LVMAAPATLM VLGNSLLRQF DSSHEIRTGA AAAAQALGPG
     ALGPVQVLVR FDAGGASAPE HSQTIAAIRH RIAQAPNVVS VAPPRFADDN GSALLSAVLS
     VDPEDLGARD TITWMRTQLP RVAGAAQVDV GGPTALIKDF DDRVSATQPL VLVFVAVIAF
     LMLLISIRSV FLAFKGVLMT LLSVAAAYGS LVMVFQWGWA RGLGFPALHS IDSTVPPLVL
     AMTFGLSMDY EIFLLTRIRE RFLQTGQTRD AVAYGVRTSA RTITSAALIM IAVFCGFAFA
     GMPLVAEIGV ACAVAIAVDA TVVRLVLVPA LMAMFDRWNW WLPRWLAHIL PSVDFDRPLP
     KVDLGDVVVI PDDFAAAIPP SADVRMVLKS AAKLKRLAPD AICVTDPLAF TGCGCDGKAL
     DQVQLAYRNG IARAISWGQR PVHPVTVWRK RLAVALDALQ TTTWECGGVQ THRAGPGYRR
     RSPVETTNVA LPTGDRLQIP TGAETLRFKG YLIMSRNSSH DYADFADLVD TMAPETAAAV
     LAGMDRYYSC QAPGRQWMAT QLVGRLADPQ PSDLGDQSPG ADAQAKWEEV RRRCLSVAVA
     MLEEAR