ID   MMPLB_STRCO             Reviewed;         847 AA.
AC   O54101;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Putative membrane protein SCO5905;
GN   OrderedLocusNames=SCO5905; ORFNames=SC10A5.10c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL939125; CAA16442.1; -; Genomic_DNA.
DR   PIR; T34577; T34577.
DR   RefSeq; NP_630023.1; NC_003888.3.
DR   RefSeq; WP_011030524.1; NZ_VNID01000007.1.
DR   AlphaFoldDB; O54101; -.
DR   SMR; O54101; -.
DR   STRING; 100226.SCO5905; -.
DR   PRIDE; O54101; -.
DR   GeneID; 1101347; -.
DR   KEGG; sco:SCO5905; -.
DR   PATRIC; fig|100226.15.peg.6003; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_4_0_11; -.
DR   InParanoid; O54101; -.
DR   OMA; TIAFEIW; -.
DR   PhylomeDB; O54101; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023845; DUF3817_TM.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF12823; DUF3817; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR03954; integ_memb_HG; 1.
DR   PROSITE; PS50156; SSD; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..847
FT                   /note="Putative membrane protein SCO5905"
FT                   /id="PRO_0000103582"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        562..582
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        600..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        643..663
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        672..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        744..764
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        778..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        808..828
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          708..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   847 AA;  88617 MW;  E2A443F5C74AE1DE CRC64;
     MNSPALLRCL LGSKKRAAVV VAFWVLIAGL LAGVAPALES VEDNASANLP PAASDSMKAR
     DLVRAQLPGQ DATPAIIVVR GKGTDAAKSA TQSVAAITSA LSGTSRPDHV VSVVSTVTAP
     DAAAELVSQD RGAQLVIVPM EGSPSDESFQ NAVDEVRALA SDRAGPADVA VTGPAGIATD
     TVKVFSGGDK VLLLATVVLV LIILLAIYRS PLMALVPLLA VGVAMRVAET LGAILADAGV
     ITVSSQTASI MTVLLFGVGT DYALIITARY RETLLDEPDR ARAMQAAVRR TAESVLASAS
     TIVLAMFALL VAVSPALHGF GPYLALGVAV MALVAFTFIP ALVLLLGRSV FWPGGVDKAA
     ERSRGAGIWH RIAALVARAP VKVASAVIAL LVVLSAGLLG YQESFNTLSG FRAATESEHG
     QHLIREEFGP GEIAPSTVVV HSQDNLRSSP APADIATALT DADHVSRVAD PRMGKDGKTV
     FYDVILDLDP YSSKALDAIG PLKQATQSAA QAAGVQDATV LIGGETAQNA DIRSALDRDT
     TLIVLLVLAI VTVVLVLLLR SLLAPLYLVA TLLLSFLATL GATTFFTVTV LGDDGIGNRV
     TAYIFVFLVA LGVDYNIFIM SRFKQELRTQ PPAKAITAAL TRTGGVISSA GLILAATFAV
     LMTQPIRELF QFGFAMACGI LLDTFLIRPL LVPAIVRLLG NRALWPARPG TPQTPSTPTS
     EPPSADAPAA RAAETGTSRL LRAFTWIAII EACTWAGLLA GMYLKYIPET TELGVRIFGT
     LHGAAFIVYV SLTVLVAIRL KWRLGRTTIF ALLAAVPPFM TIAFEIWARR TGRLPQPTAD
     PSPTPAL