ID   MMPLC_MYCTU             Reviewed;        1146 AA.
AC   P9WJT7; L0T6X0; Q50585;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Probable transport protein MmpL12 {ECO:0000305};
GN   Name=mmpL12; OrderedLocusNames=Rv1522c; ORFNames=MTCY19G5.06;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44286.1; -; Genomic_DNA.
DR   PIR; B70723; B70723.
DR   RefSeq; NP_216038.1; NC_000962.3.
DR   RefSeq; WP_003898915.1; NZ_NVQJ01000004.1.
DR   AlphaFoldDB; P9WJT7; -.
DR   STRING; 83332.Rv1522c; -.
DR   PaxDb; P9WJT7; -.
DR   DNASU; 886445; -.
DR   GeneID; 886445; -.
DR   KEGG; mtu:Rv1522c; -.
DR   TubercuList; Rv1522c; -.
DR   eggNOG; COG1033; Bacteria.
DR   eggNOG; COG1511; Bacteria.
DR   eggNOG; COG2409; Bacteria.
DR   OMA; MHLIEIA; -.
DR   PhylomeDB; P9WJT7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052572; P:response to host immune response; IMP:MTBBASE.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1146
FT                   /note="Probable transport protein MmpL12"
FT                   /id="PRO_0000103580"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        826..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        850..870
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        883..903
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        928..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        949..969
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1146 AA;  122430 MW;  AC03075641C5CB09 CRC64;
     MARHDEAKAG GLFDRIGNFV VRWPLIVIGC WIAVAAALTL LLPTLQAQAA KREQAPLPPG
     APSMVLQKEM SAAFQEKIET SALLLVLLTN ENGLGPADEA VYRKLIENLR ADTQDKISVQ
     DFLAVPEMKE LLASKDNKAW NLPITFAGDA ASPETQAAFK RVAAIVKQTV AGTSLTVHLS
     GPIATVADLT ELGEKDVRII EIGTAVSVLI ILILVYRNLV TMLVPLATIG ASVVTAQGTL
     SGLAEFGLAV NMQAIVFMSA VMIGAGTDYA VFLISRYHDY VRHGEKSDMA VKKALMSIGK
     VITASAATVA VTFLAMVFTK LEVFSAVGPA IAVAITVSLL GAVTLLPAIL TLTGRRGWIK
     PRRDLTSRMW RRSGVRIVRR STIHLVGSLI VLVALAGCTL LIRFNYDDLK TVPQHVESVK
     GYEAMNRHFP MNAMTPMVLF IKSPRDLRTP GALADIEMMS REIAELPNIV MVRGLTRPNG
     EPLKETKVSF QAGEVGGKLD EATTLLEEHG GELDQLTGGA HQLADALAQI RNEINGAVAS
     SSGIVNTLQA MMDLMGGDKT IRQLENASQY VGRMRALGDN LSGTVTDAEQ IATWASPMVN
     ALNSSPVCNS DPACRTSRAQ LAAIVQAQDD GLLRSIRALA VTLQQTQEYQ TLARTVSTLD
     GQLKQVVSTL KAVDGLPTKL AQMQQGANAL ADGSAALAAG VQELVDQVKK MGSGLNEAAD
     FLLGIKRDAD KPSMAGFNIP PQIFSRDEFK KGAQIFLSAD GHAARYFVQS ALNPATTEAM
     DQVNDILRVA DSARPNTELE DATIGLAGVP TALRDIRDYY NSDMKFIVIA TIVIVFLILV
     ILLRALVAPI YLIGSVLISY LSALGIGTLV FQLILGQEMH WSLPGLSFIL LVAIGADYNM
     LLISRIRDES PHGIRIGVIR TVGSTGGVIT SAGLIFAASM FGLVGASINT MAQAGFTIGI
     GIVLDTFLVR TVTVPALTTM IGRANWWPSE LGRDPSTPPT KADRWLRRVK GHRRKAPIPA
     PKPPHTKVVR NTNGHASKAA TKSVPNGKPA DLAEGNGEYL IDHLRRHSLP LFGYAAMPAY
     DVVDGVSKPN GDGAHIGKEP VDHLLGHSLP LFGLAGLPSY DRWDDTSIGE PAVGHAGSKP
     DAKLST