ID   MMPLC_STRCO             Reviewed;         705 AA.
AC   O88022;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Putative membrane protein SCO6666;
GN   OrderedLocusNames=SCO6666; ORFNames=SC5A7.16c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL939128; CAA19945.1; -; Genomic_DNA.
DR   PIR; T35165; T35165.
DR   RefSeq; NP_630741.1; NC_003888.3.
DR   RefSeq; WP_011031089.1; NZ_VNID01000002.1.
DR   AlphaFoldDB; O88022; -.
DR   SMR; O88022; -.
DR   STRING; 100226.SCO6666; -.
DR   GeneID; 1102105; -.
DR   KEGG; sco:SCO6666; -.
DR   PATRIC; fig|100226.15.peg.6772; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_1_1_11; -.
DR   InParanoid; O88022; -.
DR   OMA; KDGIAHS; -.
DR   PhylomeDB; O88022; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF03176; MMPL; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..705
FT                   /note="Putative membrane protein SCO6666"
FT                   /id="PRO_0000103583"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        504..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        561..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        615..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        636..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   705 AA;  73118 MW;  B1935ACE0F75390E CRC64;
     MLSTLARAAT RRPLTVMLLW GLFLLLGFGL GTGVFGRLSD DVPDVPGTES QVAAEHLDGL
     DPAGDSITGV VEAAAVADPA VRAEVRRAVA DLREVAGVAE VPDPYATPGT VAEDGRALVV
     SVTLEGGLDD DAEEAAVDDA ADRLHGIDGS AVSGVHVSGG PLLGQQLGER AQEDVKNAEL
     ISLPVVLVLL LVVFGGLRAA GLPLLVAVAG IAGAFLALFG FSHVTDISVY AIQVTTMLGL
     GLAVDYALLM LVRFREERRH IPDVVEAVHR TVAAAGRTVL FSGLTVAVSL AGLLVFPSTF
     LRSMGLAVAA VVVVDMLAAL TLLPALLTRF GGRIPPAKAR PEEEGRLFAR LARFAARRRV
     AVLAVAVPAL LVVALPVTGM SINLGDARQL PKSTEARQLY DAIEAHFPPG TGVSPVTVVL
     RPGTDTATAD RIGAIAGGTT VRDLPGGTTV LELPAGGAAD GPAATELVER VRDLRGDAPV
     QVTGSAAQLV DFRQMLADRA PWAALTVLTG IFVLLFAFTG SVLLPLRTVA TTLLSLGAAL
     GAVVWVFQDG HLAGPIGAEG LGALSLTAPP LIIAIAFGLA MDYELFILAR MREARERTGD
     DREAVVTGLR RSGRVVTCAA LLLAVVFGAF MTGGFSPILQ IGLGLTLAVL IDATVVRMLL
     VPATMALLGR HAWWAPKPLR RAHERFGVRE EAPGPAPAPP QPAAR