ID   MMPS2_MYCTU             Reviewed;         145 AA.
AC   P9WJT3; L0T6P6; P65376; Q11170;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Probable transport accessory protein MmpS2 {ECO:0000305};
GN   Name=mmpS2; OrderedLocusNames=Rv0506; ORFNames=MTCY20G9.33;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   INDUCTION.
RC   STRAIN=H37Rv;
RX   PubMed=24737322; DOI=10.1074/jbc.m113.538959;
RA   Radhakrishnan A., Kumar N., Wright C.C., Chou T.H., Tringides M.L.,
RA   Bolla J.R., Lei H.T., Rajashankar K.R., Su C.C., Purdy G.E., Yu E.W.;
RT   "Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium
RT   tuberculosis.";
RL   J. Biol. Chem. 289:16526-16540(2014).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Transcriptionally regulated by MmpR5.
CC       {ECO:0000269|PubMed:24737322}.
CC   -!- SIMILARITY: Belongs to the MmpS family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP43243.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP43243.1; ALT_INIT; Genomic_DNA.
DR   PIR; E70746; E70746.
DR   RefSeq; NP_215020.1; NC_000962.3.
DR   AlphaFoldDB; P9WJT3; -.
DR   SMR; P9WJT3; -.
DR   STRING; 83332.Rv0506; -.
DR   PaxDb; P9WJT3; -.
DR   DNASU; 887279; -.
DR   GeneID; 887279; -.
DR   KEGG; mtu:Rv0506; -.
DR   PATRIC; fig|83332.12.peg.562; -.
DR   TubercuList; Rv0506; -.
DR   eggNOG; ENOG5030G8G; Bacteria.
DR   OMA; PKALTFC; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.2880; -; 1.
DR   InterPro; IPR008693; MmpS.
DR   InterPro; IPR038468; MmpS_C.
DR   Pfam; PF05423; Mycobact_memb; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..145
FT                   /note="Probable transport accessory protein MmpS2"
FT                   /id="PRO_0000216153"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   145 AA;  15676 MW;  9EE1CCFADC85F90B CRC64;
     MISVSGAVKR MWLLLAIVVV AVVGGLGIYR LHSIFGVHEQ PTVMVKPDFD VPLFNPKRVT
     YEVFGPAKTA KIAYLDPDAR VHRLDSVSLP WSVTVETTLP AVSVNLMAQS NADVISCRII
     VNGAVKDERS ETSPRALTSC QVSSG