MMR_BACSU
ID MMR_BACSU Reviewed; 466 AA.
AC Q00538;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Methylenomycin A resistance protein;
DE AltName: Full=MMR peptide;
GN Name=mmr; OrderedLocusNames=BSU37570;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=1379177; DOI=10.1002/j.1460-2075.1992.tb05384.x;
RA Putzer H., Gendron N., Grunberg-Manago M.;
RT "Co-ordinate expression of the two threonyl-tRNA synthetase genes in
RT Bacillus subtilis: control by transcriptional antitermination involving a
RT conserved regulatory sequence.";
RL EMBO J. 11:3117-3127(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Resistance to the epoxide antibiotic methylenomycin.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000305}.
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DR EMBL; X66121; CAA46908.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15784.1; -; Genomic_DNA.
DR PIR; I40493; YTBSMA.
DR RefSeq; NP_391637.1; NC_000964.3.
DR RefSeq; WP_003243441.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; Q00538; -.
DR SMR; Q00538; -.
DR STRING; 224308.BSU37570; -.
DR TCDB; 2.A.1.3.10; the major facilitator superfamily (mfs).
DR PaxDb; Q00538; -.
DR PRIDE; Q00538; -.
DR EnsemblBacteria; CAB15784; CAB15784; BSU_37570.
DR GeneID; 937101; -.
DR KEGG; bsu:BSU37570; -.
DR PATRIC; fig|224308.179.peg.4069; -.
DR eggNOG; COG0477; Bacteria.
DR InParanoid; Q00538; -.
DR OMA; IMFRAMS; -.
DR PhylomeDB; Q00538; -.
DR BioCyc; BSUB:BSU37570-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 2.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..466
FT /note="Methylenomycin A resistance protein"
FT /id="PRO_0000173364"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 466 AA; 48845 MW; 7F77702100736799 CRC64;
MKNSGSIQES TSSTGISVLI VLALGFLMAT LDVTVVNVAM ADMKNTLSMS LSGVTWVVDG
YILTFASLLL AGGALADRFG SKTIYILGLA VFVMASCLCA ASINGQMLIA GRLIQGIGAA
LFMPSSLSLL AASYLDERAR ARMFGLWAAL VSAASALGPF IGGVLVQLAG WQSIFLINVP
IGAAALISAY RILSRVPGKS SRVNIIGHLL GMMALGFLSY ALIQGPSAGW RSPVILVAFT
AAVLAFVLFL LREISAKTPI LPASLYKNGR FSAAQFIGFL LNFALFGGMF MLSLFLQEAG
GASSFMAGVE LLPMMAVFVI GNLLFARLAN RFEAGQLMFV SMAVSCIIAL LLFVLISPDF
PYWQLAVLMS VMNLCTGITV PAMTTVIMQA AGQRHTNIAG AALNANRQIG ALVGVAITGV
IIHLSATWYA GAGFAFLMMG AAYSLAALLV WLFLAAHNGT AASEKM
