ID   MMR_MYCBO               Reviewed;         107 AA.
AC   P69927; A0A1R3Y365; P95094; X2BN92;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Multidrug resistance protein mmr;
GN   Name=mmr; OrderedLocusNames=BQ2027_MB3092;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Multidrug efflux pump. Confers resistance to
CC       tetraphenylphosphonium (TPP), erythromycin, ethidium bromide,
CC       acriflavine, safranin O and pyronin Y (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr
CC       subfamily. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01717.1; -; Genomic_DNA.
DR   RefSeq; NP_856737.1; NC_002945.3.
DR   RefSeq; WP_003415995.1; NC_002945.4.
DR   AlphaFoldDB; P69927; -.
DR   SMR; P69927; -.
DR   EnsemblBacteria; SIU01717; SIU01717; BQ2027_MB3092.
DR   GeneID; 45427058; -.
DR   PATRIC; fig|233413.5.peg.3397; -.
DR   OMA; ATTAMKY; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..107
FT                   /note="Multidrug resistance protein mmr"
FT                   /id="PRO_0000108117"
FT   TRANSMEM        2..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  11083 MW;  3D372AC2FAE89834 CRC64;
     MIYLYLLCAI FAEVVATSLL KSTEGFTRLW PTVGCLVGYG IAFALLALSI SHGMQTDVAY
     ALWSAIGTAA IVLVAVLFLG SPISVMKVVG VGLIVVGVVT LNLAGAH