ID   MMR_MYCLE               Reviewed;         107 AA.
AC   Q9CBP1;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Multidrug resistance protein mmr;
GN   Name=mmr; OrderedLocusNames=ML1756;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Multidrug efflux pump. Confers resistance to
CC       tetraphenylphosphonium (TPP), erythromycin, ethidium bromide,
CC       acriflavine, safranin O and pyronin Y (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AL583923; CAC30709.1; -; Genomic_DNA.
DR   RefSeq; NP_302204.1; NC_002677.1.
DR   RefSeq; WP_010908525.1; NC_002677.1.
DR   AlphaFoldDB; Q9CBP1; -.
DR   SMR; Q9CBP1; -.
DR   STRING; 272631.ML1756; -.
DR   EnsemblBacteria; CAC30709; CAC30709; CAC30709.
DR   KEGG; mle:ML1756; -.
DR   PATRIC; fig|272631.5.peg.3315; -.
DR   Leproma; ML1756; -.
DR   eggNOG; COG2076; Bacteria.
DR   HOGENOM; CLU_133067_0_1_11; -.
DR   OMA; ATTAMKY; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..107
FT                   /note="Multidrug resistance protein mmr"
FT                   /id="PRO_0000108118"
FT   TRANSMEM        2..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  11191 MW;  0DD4256334CF61C2 CRC64;
     MAYLFLFCAI FVEVVATTLL KSTEGFTRLV PTLACLAGYA VTFTLLALSI SRGMKTDVAY
     ALWSAIGTAA IVLIAVLFLD SPVSVAKVVG VALIIVGVIT LNLADAH