ID   MMR_MYCPA               Reviewed;         107 AA.
AC   Q73V87;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Multidrug resistance protein mmr;
GN   Name=mmr; Synonyms=emrE; OrderedLocusNames=MAP_3127;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Multidrug efflux pump. Confers resistance to
CC       tetraphenylphosphonium (TPP), erythromycin, ethidium bromide,
CC       acriflavine, safranin O and pyronin Y (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS05675.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016958; AAS05675.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_003874907.1; NC_002944.2.
DR   AlphaFoldDB; Q73V87; -.
DR   SMR; Q73V87; -.
DR   STRING; 262316.MAP_3127; -.
DR   EnsemblBacteria; AAS05675; AAS05675; MAP_3127.
DR   GeneID; 66695157; -.
DR   KEGG; mpa:MAP_3127; -.
DR   eggNOG; COG2076; Bacteria.
DR   HOGENOM; CLU_133067_0_1_11; -.
DR   OMA; ATTAMKY; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..107
FT                   /note="Multidrug resistance protein mmr"
FT                   /id="PRO_0000108119"
FT   TRANSMEM        2..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  11153 MW;  1B3F7A292F6D32B7 CRC64;
     MTYLFLICAI LAEVVATSLL KSTQGFTRLW PTVICLLGYA VSFALLAVSI SRGMQTDVAY
     ALWSAIGTAL IVLIAVLFLG SPISVTKVVG VGLIIAGVVT LNLTGAH