MMS19_ARATH
ID MMS19_ARATH Reviewed; 1134 AA.
AC Q0WVF8; Q9FI26;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=MMS19 nucleotide excision repair protein homolog {ECO:0000305};
DE AltName: Full=MET18 homolog {ECO:0000303|PubMed:23104832};
DE AltName: Full=MMS19-like protein {ECO:0000305};
GN Name=MMS19 {ECO:0000305}; Synonyms=MET18 {ECO:0000303|PubMed:23104832};
GN OrderedLocusNames=At5g48120 {ECO:0000312|Araport:AT5G48120};
GN ORFNames=MDN11.21 {ECO:0000312|EMBL:BAB11076.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAE98890.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INTERACTION WITH AE7, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=23104832; DOI=10.1105/tpc.112.102608;
RA Luo D., Bernard D.G., Balk J., Hai H., Cui X.;
RT "The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster
RT assembly pathway to maintain nuclear genome integrity in Arabidopsis.";
RL Plant Cell 24:4135-4148(2012).
CC -!- FUNCTION: May select specific target apoproteins to which a Fe-S
CC cluster produced by the cytosolic iron-sulfur (Fe-S) protein assembly
CC (CIA) pathway is transferred. {ECO:0000269|PubMed:23104832}.
CC -!- SUBUNIT: Part of a complex composed of AE7, CIA1, MMS19 and NAR1.
CC Interacts with AE7. {ECO:0000269|PubMed:23104832}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23104832}. Cytoplasm
CC {ECO:0000269|PubMed:23104832}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:23104832}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11076.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB017064; BAB11076.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB023039; BAB11076.1; JOINED; Genomic_DNA.
DR EMBL; CP002688; AED95621.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69256.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69257.1; -; Genomic_DNA.
DR EMBL; AK226792; BAE98890.1; -; mRNA.
DR RefSeq; NP_001318759.1; NM_001344759.1.
DR RefSeq; NP_001330951.1; NM_001344760.1.
DR RefSeq; NP_199623.2; NM_124186.5.
DR AlphaFoldDB; Q0WVF8; -.
DR SMR; Q0WVF8; -.
DR STRING; 3702.AT5G48120.1; -.
DR PaxDb; Q0WVF8; -.
DR PRIDE; Q0WVF8; -.
DR ProteomicsDB; 250752; -.
DR EnsemblPlants; AT5G48120.1; AT5G48120.1; AT5G48120.
DR EnsemblPlants; AT5G48120.2; AT5G48120.2; AT5G48120.
DR EnsemblPlants; AT5G48120.3; AT5G48120.3; AT5G48120.
DR GeneID; 834864; -.
DR Gramene; AT5G48120.1; AT5G48120.1; AT5G48120.
DR Gramene; AT5G48120.2; AT5G48120.2; AT5G48120.
DR Gramene; AT5G48120.3; AT5G48120.3; AT5G48120.
DR KEGG; ath:AT5G48120; -.
DR Araport; AT5G48120; -.
DR TAIR; locus:2162697; AT5G48120.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_0_0_1; -.
DR InParanoid; Q0WVF8; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 944339at2759; -.
DR PhylomeDB; Q0WVF8; -.
DR PRO; PR:Q0WVF8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q0WVF8; baseline and differential.
DR Genevisible; Q0WVF8; AT.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; PTHR12891; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1134
FT /note="MMS19 nucleotide excision repair protein homolog"
FT /id="PRO_0000433516"
FT REPEAT 959..998
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 1002..1047
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 1050..1089
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 1092..1130
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1134 AA; 124255 MW; 0FBB9559E03FD15F CRC64;
MMVEPNQLVQ HLETFVDTNR SSSQQDDSLK AIASSLENDS LSITQLVREM EMYLTTTDNL
VRARGILLLA EILDCLKAKP LNDTIVHTLV GFFSEKLADW RAMCGALVGC LALLKRKDVA
GVVTDIDVQA MAKSMIQNVQ VQALALHERK LAFELLECLL QQHSEAILTM GDLLVYAMCE
AIDGEKDPQC LMIVFHLVEL LAPLFPSPSG PLASDASDLF EVIGCYFPLH FTHTKDDEAN
IRREDLSRGL LLAISSTPFF EPYAIPLLLE KLSSSLPVAK VDSLKCLKDC ALKYGVDRMK
KHYGALWSAL KDTFYSSTGT HLSFAIESLT SPGFEMNEIH RDAVSLLQRL VKQDISFLGF
VVDDTRINTV FDTIYRYPQY KEMPDPSKLE VLVISQILSV SAKASVQSCN IIFEAIFFRL
MNTLGIVEKT STGDVVQNGN STVSTRLYHG GLHLCIELLA ASKDLILGFE ECSPTSGCAN
SGCSMVKSFS VPLIQVFTSA VCRSNDDSVV DVYLGVKGLL TMGMFRGGSS PVSRTEFENI
LVTLTSIITA KSGKTVVWEL ALKALVCIGS FIDRYHESDK AMSYMSIVVD NLVSLACSSH
CGLPYQMILE ATSEVCSTGP KYVEKMVQGL EEAFCSSLSD FYVNGNFESI DNCSQLLKCL
TNKLLPRVAE IDGLEQLLVH FAISMWKQIE FCGVFSCDFN GREFVEAAMT TMRQVVGIAL
VDSQNSIIQK AYSVVSSCTL PAMESIPLTF VALEGLQRDL SSRDELILSL FASVIIAASP
SASIPDAKSL IHLLLVTLLK GYIPAAQALG SMVNKLGSGS GGTNTSRDCS LEEACAIIFH
ADFASGKKIS SNGSAKIIVG SETTMSKICL GYCGSLDLQT RAITGLAWIG KGLLMRGNER
VNEIALVLVE CLKSNNCSGH ALHPSAMKHA ADAFSIIMSD SEVCLNRKFH AVIRPLYKQR
CFSTIVPILE SLIMNSQTSL SRTMLHVALA HVISNVPVTV ILDNTKKLQP LILEGLSVLS
LDSVEKETLF SLLLVLSGTL TDTKGQQSAS DNAHIIIECL IKLTSYPHLM VVRETSIQCL
VALLELPHRR IYPFRREVLQ AIEKSLDDPK RKVREEAIRC RQAWASITSG SNIF
