ID   MMS19_DICDI             Reviewed;        1115 AA.
AC   Q54J88;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=MMS19 nucleotide excision repair protein homolog;
DE   AltName: Full=MMS19-like protein;
GN   Name=mms19; ORFNames=DDB_G0288217;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family. {ECO:0000305}.
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DR   EMBL; AAFI02000109; EAL63339.2; -; Genomic_DNA.
DR   RefSeq; XP_636848.2; XM_631756.2.
DR   AlphaFoldDB; Q54J88; -.
DR   SMR; Q54J88; -.
DR   STRING; 44689.DDB0235234; -.
DR   PaxDb; Q54J88; -.
DR   PRIDE; Q54J88; -.
DR   EnsemblProtists; EAL63339; EAL63339; DDB_G0288217.
DR   GeneID; 8626516; -.
DR   KEGG; ddi:DDB_G0288217; -.
DR   dictyBase; DDB_G0288217; mms19.
DR   eggNOG; KOG1967; Eukaryota.
DR   HOGENOM; CLU_005943_0_0_1; -.
DR   InParanoid; Q54J88; -.
DR   OMA; FSFMPEF; -.
DR   PhylomeDB; Q54J88; -.
DR   PRO; PR:Q54J88; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006259; P:DNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; PTHR12891; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Nucleus; Reference proteome; Repeat;
KW   Transcription.
FT   CHAIN           1..1115
FT                   /note="MMS19 nucleotide excision repair protein homolog"
FT                   /id="PRO_0000356170"
FT   REPEAT          944..986
FT                   /note="HEAT 1"
FT   REPEAT          990..1032
FT                   /note="HEAT 2"
FT   REPEAT          1035..1075
FT                   /note="HEAT 3"
FT   REPEAT          1078..1115
FT                   /note="HEAT 4"
FT   REGION          587..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1115 AA;  127373 MW;  2AE75FD6A079A34F CRC64;
     MTSNITELNK WIEGYVNPQS EESVKTNAIN MVLLYMKSNK IDLQDVVQGL GDYLKSNDSI
     LRARGTLLLS EVLCRLPDLP LNQDQVHFLA MFYCDRLQDY ACSSEVVKGI TGLITNHTPD
     YPDNQKLLRN IFSEVHPTSL TQAHRKMVLQ VIDIMFNKCL SEIQELKNDF MVGYLQFIDN
     EKDPRNLIFS FKLLPKVIYN IPEHKHFLES LFEIISCYFP ISFNPKGNDP NSITKDDLSN
     SLLNCFSCTP LLAEHSIPFL IDKICSNLIE TKIEALQTLV YCCDRYGGFA VQPFLEEIWS
     TLRTLILTHK NTTVIEESKK TIFYLTRSFT KERKVLESFL SIMIKECLHH IKSSQDSKIA
     IYCASILYQS VSASLLSSKI ILIHIFPNLF NFLSELQKQD TVQKVNEQNS VIALFNDLLK
     ANSIAFEMYS NENKEPNPLE PFVDQLFKLF SDLLLLNSSS SIRSNSIECL SNLYISKKVH
     TTEQDDDDSE QITNEFLLDL EKRQFIIKSL VSLLNSSDNT LRHKSLDSLF TIASNEDPSV
     LNLYVIPTLL QMINHSSCNI NTTNNKINNN NNNNNIVIKN NKCQDEHCNE DHSNKNENNN
     NSNENSNGNS TSGSDDDLKH YLEAFTKLCT HQPLLESVIP QIQVLLQHNI KETYQSNEDF
     EKSILILQSI SFILEKSTNI KSMTICSKSI LFPLIKGLYK QELISSSNDN NNNNNNNSNR
     FNQILTPTLK MIHSIFENIS IESQKPLLEK LIKLFLNGDT LVINYQLPTT TTTIIKPFEK
     SSPYKYLIPI FTTIISQSKL DLSENNELKQ SLYQMSLDVN VDDSIAISCS KAYSSIINKQ
     QQQQQQDQIN FNFFNDNLLK VINDTTTPLP LKIRHLDLFT WCTKALLTNG NSINIKLGSC
     LADIISNENV ELSYHASKSF GILLSETDVL NEKSGSIIKI LFEQKFFTLM FPILLESFKV
     SKNKELQTIS SHYLIAISNL LKHVPKEILL AELNEILPIV MQSLKSSDNN DQVQLLDSSL
     QTLTMLINET PSSFISYLDS LIPSLIKIST KSTKYNLKRS ALEILTLLSK SIPFVNLFPY
     KTQVVTDIIP CLDDKKRIVR REAQKCRNSW YILQK