ID   MMS19_XENLA             Reviewed;        1022 AA.
AC   Q6DCF2;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=MMS19 nucleotide excision repair protein homolog;
DE   AltName: Full=MMS19-like protein;
GN   Name=mms19;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins (By similarity).
CC       {ECO:0000250|UniProtKB:Q96T76}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000250|UniProtKB:Q96T76}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96T76}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q96T76}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family. {ECO:0000305}.
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DR   EMBL; BC078095; AAH78095.1; -; mRNA.
DR   RefSeq; NP_001087156.1; NM_001093687.1.
DR   AlphaFoldDB; Q6DCF2; -.
DR   SMR; Q6DCF2; -.
DR   DNASU; 447045; -.
DR   GeneID; 447045; -.
DR   CTD; 447045; -.
DR   Xenbase; XB-GENE-979263; mms19.L.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 447045; Expressed in ovary and 19 other tissues.
DR   GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006259; P:DNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; PTHR12891; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1022
FT                   /note="MMS19 nucleotide excision repair protein homolog"
FT                   /id="PRO_0000419482"
FT   REPEAT          858..896
FT                   /note="HEAT 1"
FT   REPEAT          900..938
FT                   /note="HEAT 2"
FT   REPEAT          941..979
FT                   /note="HEAT 3"
FT   REPEAT          982..1020
FT                   /note="HEAT 4"
SQ   SEQUENCE   1022 AA;  113047 MW;  17FBB66B1EC3648E CRC64;
     MAEAQTALWG LVEEFVVGEQ DSKSAEVAAG VKDGVFTVLQ VVESLGSCLA NPEPRMRSKG
     VQLLSRVLLE CYSRLTEKEV EVLVVFYENR LKDHHLITPH VLQGLMALSM CDVLPQGVAV
     SVLKSVFQEV HVQSLMQIDR HTVYMIITNF MKTREEELKN LGADFTYGFI QVMDGEKDPR
     NLLVAFYIVQ DIVTKNYALG PFVEELFEVT SCYFPIDFTP PPSDPHGITR EHLIMGLRAV
     LASTSRFAEF LLPLLIEKMD SEMQSAKLDS LQTLSACCTV YGQKELKEFL SGLWSSIRRE
     VFQTASEKIE AEGLAALQAL SACLSRSVLS PDAEDLLDSF LNNILQDCKH HLCEPDMKLV
     WPSAKLLQAA AGGSSRACWK VTANVLPLLL EQYNQHAQSS HRRTILEMTL GFLKLQSRWL
     DEEDENGLGN LKESLCSMVF SAVTDSSTQL HVVALKILTV LAMQQGFMAS SDIDLVVDHL
     TRLILQKTDS ESCMAAVEAS GTLAKVHPSA FISRMLPQLC ANLQTEPMDI NLNESGVVPE
     HSIRQLCLEA LAAVSTHQSI LKETVPILLD YIRRAHNGEE ETNVENVVSV CKSLHRVAVQ
     CQLDSESLQF YHQTVLPCLL SLTVQAATQD SGTSSHILLR DDILTAMVPV ISAACTHLKP
     ELASKSTSQI VSLFLDGDIS LLSENNFSSK FQPFQVNGPT ELQNRLVSLL MAFICSLPRN
     VEIPHLRRLL QHLLSLSLSG CSLFAYSSAS KCFAGLINKC PQGDLLDDIL KVTAQRIDVG
     LVEEPSRTQA ITLLVWVTKA LVLRYHPLSG QLTDKMIGLL SDQQLGPSVA NMFSLLVSDS
     PDILNKACHA DIRIMFRQRF FTENVPKLVQ GFNSANGDDK PNYLKALSHV LNTLPKQVLM
     PELPSLLSLL LEALSCPDKV VQLSTLICLE PLLQEAPETL KVHIDGLISK LLGLSCSPAM
     AVRITALKCI LALTKLPLHM LLPYKQQVIR ALAKPLDDKK RLVRKEAVET RCQWFLLGSP
     GS