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MMS19_XENTR
ID   MMS19_XENTR             Reviewed;        1022 AA.
AC   Q0V9L1; F6SGZ4;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=MMS19 nucleotide excision repair protein homolog;
DE   AltName: Full=MMS19-like protein;
GN   Name=mms19;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins (By similarity).
CC       {ECO:0000250|UniProtKB:Q96T76}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000250|UniProtKB:Q96T76}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96T76}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q96T76}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family. {ECO:0000305}.
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DR   EMBL; AAMC01095614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01095615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01095616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01095617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC121492; AAI21493.1; -; mRNA.
DR   RefSeq; NP_001072380.1; NM_001078912.1.
DR   AlphaFoldDB; Q0V9L1; -.
DR   SMR; Q0V9L1; -.
DR   STRING; 8364.ENSXETP00000007443; -.
DR   PaxDb; Q0V9L1; -.
DR   DNASU; 779833; -.
DR   GeneID; 779833; -.
DR   KEGG; xtr:779833; -.
DR   CTD; 64210; -.
DR   Xenbase; XB-GENE-979258; mms19.
DR   eggNOG; KOG1967; Eukaryota.
DR   HOGENOM; CLU_005943_2_0_1; -.
DR   InParanoid; Q0V9L1; -.
DR   OrthoDB; 944339at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0071817; C:MMXD complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006259; P:DNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; PTHR12891; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1022
FT                   /note="MMS19 nucleotide excision repair protein homolog"
FT                   /id="PRO_0000419483"
FT   REPEAT          858..896
FT                   /note="HEAT 1"
FT   REPEAT          900..938
FT                   /note="HEAT 2"
FT   REPEAT          941..979
FT                   /note="HEAT 3"
FT   REPEAT          982..1020
FT                   /note="HEAT 4"
FT   CONFLICT        771
FT                   /note="Q -> L (in Ref. 2; AAI21493)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1022 AA;  113131 MW;  2F219479D86B6D3D CRC64;
     MAEAHSALWG LVEEFVVGEQ DSRSAEVAAG VKDGIFTVLQ VVEALGSCLA NPEPRSRAKG
     MQLLSRVLLE CYSRLTEKEV EVLVLFYENR LKDHHLITPH VLKGLMALSM CDVLPQGLAV
     SVLKSVFQEV HVQSLMQIDR HTVYMIITNF MKTREEELKS LGADFTYGFI QVMDGEKDPR
     NLLVAFHIVQ DIITKNYALG PFVEELFEVT SCYFPIDFTP PPNDPHGITR EHLIVGLRAV
     LVSTSRFAEF FLPLLIEKMD SDVQSAKLDS LQTLIACCTV YGQKDLKEFL SGLWSSIRRE
     VFQTASEKIE AEGLAALQAL SACLSRSILS PDAEDLLDSF LNSILQDCKH HLCEPDMKLV
     WPSAKLLQAA AGGSSRACWK VTANVLPLLL EQYNQHAQSS HRRTILEMTL GFLKLQSRWL
     DEEDDNGLGN LKEALCTMVF SAVTDSSTQL HQVAVRTLTV LAMQQGFLSS SDIDLVVDHL
     TRLILQETDS ESCMAAIEAS GTLAKVHPSV FISRMLPQLC ANLQTEPMDI NLNESRVVPE
     RFIRQRCLEA LAAVSTHQSI LKETVPILLD YIGRVHNGEG ETNAENVVSI CRSLHRVAVQ
     CQLDSEALQF YHEIVLPSLL SLTVQAATQD SGTSCNVLLR DDVLTAMVPV ITAACTHLTP
     ELASKSVSQV VALFLDGDVS LFSENNLPSN FQPFQVNGPT ELQNHLVSLL MAFVCSLPRN
     VEIPHLRRLL QHLLSLSLSG CSPFAYSSAS KCFAGLINKC PQGDLLDDIL QVTAQRIDVG
     LVDEPSRTRA ITLLVWVTKA LVLRYHPLSG QLTNKMIGLL SDKQLGPSVA NMFSLLVSDS
     PDIINKACHA DIRIMFRQRF FTENVPKLVQ GFNSANRDDK PNYLKALSHV LNALPKQVLM
     PELPSLLSLL LEALSCPDKV VQLSTLTCLE PLLQEAPETL KVHIDGLISK LVSLTLSPAM
     AVRITALKCI LALTKLPLHM LLPYKQQVIR ALAKPLDDKK RLVRKEAVET RCQWFLLGSP
     GS
 
 
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