MMS22_DROME
ID MMS22_DROME Reviewed; 1102 AA.
AC O46089; D0Z773; Q9W553;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein MMS22-like;
DE AltName: Full=Methyl methanesulfonate-sensitivity protein 22-like;
GN ORFNames=CG14803;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in recombination-dependent repair of stalled or
CC collapsed replication forks. {ECO:0000250|UniProtKB:Q6ZRQ5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6ZRQ5}.
CC Chromosome {ECO:0000250|UniProtKB:Q6ZRQ5}.
CC -!- SIMILARITY: Belongs to the MMS22 family. MMS22L subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACZ54682.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAF45677.2; -; Genomic_DNA.
DR EMBL; AL021106; CAA15938.1; -; Genomic_DNA.
DR EMBL; BT100320; ACZ54682.1; ALT_INIT; mRNA.
DR PIR; T12681; T12681.
DR RefSeq; NP_569950.1; NM_130594.2.
DR AlphaFoldDB; O46089; -.
DR BioGRID; 57688; 7.
DR DIP; DIP-21953N; -.
DR IntAct; O46089; 3.
DR STRING; 7227.FBpp0070297; -.
DR PaxDb; O46089; -.
DR PRIDE; O46089; -.
DR EnsemblMetazoa; FBtr0070310; FBpp0070297; FBgn0023513.
DR GeneID; 31142; -.
DR KEGG; dme:Dmel_CG14803; -.
DR UCSC; CG14803-RA; d. melanogaster.
DR FlyBase; FBgn0023513; CG14803.
DR VEuPathDB; VectorBase:FBgn0023513; -.
DR eggNOG; ENOG502QQCR; Eukaryota.
DR GeneTree; ENSGT00390000011769; -.
DR HOGENOM; CLU_281351_0_0_1; -.
DR InParanoid; O46089; -.
DR OMA; GFLPSNC; -.
DR OrthoDB; 523276at2759; -.
DR PhylomeDB; O46089; -.
DR BioGRID-ORCS; 31142; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 31142; -.
DR PRO; PR:O46089; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0023513; Expressed in secondary oocyte and 18 other tissues.
DR ExpressionAtlas; O46089; baseline and differential.
DR Genevisible; O46089; DM.
DR GO; GO:0043596; C:nuclear replication fork; ISS:FlyBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:FlyBase.
DR GO; GO:0031297; P:replication fork processing; ISS:FlyBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR042320; MMS22-like.
DR InterPro; IPR029424; MMS22L_C.
DR InterPro; IPR029425; MMS22L_N.
DR PANTHER; PTHR28547; PTHR28547; 1.
DR Pfam; PF14911; MMS22L_C; 1.
DR Pfam; PF14910; MMS22L_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator; Chromosome; DNA damage; DNA repair; Nucleus;
KW Reference proteome.
FT CHAIN 1..1102
FT /note="Protein MMS22-like"
FT /id="PRO_0000403774"
SQ SEQUENCE 1102 AA; 125413 MW; FDA9CD69C256BFB0 CRC64;
MDYDLFQSDD EEILATFIQA TQKQETLSAQ IDVDDSEEDL VDGLHLPEFN CSGRDTLKSQ
LCEGGFLGNG YAQLDPPRSR LDYLCFDFAP AQLAVGAVRN YLYGEACKNV QKLLTVVMGQ
QHLQATAASM NSGWYRVRQQ VTHFYHLMLL LRGNELLPSH FLDGFRQLLN DQLDADTWKV
LYFAEHNKGN DCQAPAYHLY HGVLEWRFLD LHILYASGND QAFLGQLERT LDDLIVCAGH
HYRSKHRSEL IHSSPFMCRC NKELWLLLKR LIPKWLGERE LDFWTLFHKA MQRHKSLHFQ
GESNAISLAY HELYSWLRLG LARLDEYNSE GWYQPDHSPL TAAPESFQTA SLLKQFLASQ
PDEQQRRVYL IQLSPLQLQL GKPDTDVLCQ LWEYFHRSLN CNFSVGTELD QLPLTCSNGS
AYVDRYNKLL SKSHIEDLNL SSFTMYAWML GKTLKLLPSQ GRSNQRQKLL GRIFSKFSAA
KLLALNEPGI HHVIELFLCL LLCHEDLSEL APKLREMLLC LALEKLPPVR RILVAKGHMA
LLLLHAQHRL SMDDYVSKLL NQLATIRNDA EVGAIYVGSL QAIFNLADDF NRGEQQLLGP
WLAHYVEKCG QASQDRVWQT LHNLILRLSE RRAVAGNASG IKEALQQHIM PLVRTQYVSS
HSSWLPKLAA NFIALENNGD KLLLGFLQGP EPINMAASAQ LLLQVLEDGG RPASSTILQV
WVKSLVLLNA QHESVLALMP HVTQLEEFRL LAIDPTSLEG GREPLCAFFG ALGRRAQQEE
AAAHVRMQLS HKLHAYVNHF ELWLPPDRSR SELGSRFYSF LAIVIYNCST LAYVRSKPSC
FFHLAMVRFL LTTQLQAGVP PEGRLPQVVH KIFPVLLQGI GRLPYRTDAY VAKTLEQLVQ
HWTPHFSFSS NAKLVARPYA TLLQADVDGE LAQFVLQLLV TQFLVVQRRR AGQHAGLVIT
IMQQLIESTG KEQEEQLLTV LRGVHIPLLE HVMFVDEVDL SRNQVFGLYK VLISHDAYKR
SQAVRDMCSN HLRSLAEKHL AHCTYFYFQM LINLAELAPD LVAPILSFIR EQAEQVELKR
GAGEDVGIRK CLQRLQKVLS RV
