MMS22_SCHPO
ID MMS22_SCHPO Reviewed; 1888 AA.
AC O14207;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Protein mms22;
DE AltName: Full=Protein mus7;
GN Name=mus7; Synonyms=mms22; ORFNames=SPAC6B12.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=17307401; DOI=10.1016/j.dnarep.2007.01.005;
RA Yokoyama M., Inoue H., Ishii C., Murakami Y.;
RT "The novel gene mus7(+) is involved in the repair of replication-associated
RT DNA damage in fission yeast.";
RL DNA Repair 6:770-780(2007).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17660542; DOI=10.1534/genetics.107.077255;
RA Dovey C.L., Russell P.;
RT "Mms22 preserves genomic integrity during DNA replication in
RT Schizosaccharomyces pombe.";
RL Genetics 177:47-61(2007).
CC -!- FUNCTION: Involved in protection against replication-dependent DNA
CC damage. May act by restoring active replication forks, repairing
CC unusual DNA structures, and/or preventing aberrant DNA rearrangement at
CC arrested replication forks. {ECO:0000269|PubMed:17307401,
CC ECO:0000269|PubMed:17660542}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17660542}.
CC -!- SIMILARITY: Belongs to the MMS22 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11064.1; -; Genomic_DNA.
DR PIR; T39009; T39009.
DR RefSeq; NP_593757.1; NM_001019187.2.
DR AlphaFoldDB; O14207; -.
DR BioGRID; 279665; 41.
DR STRING; 4896.SPAC6B12.02c.1; -.
DR iPTMnet; O14207; -.
DR PaxDb; O14207; -.
DR PRIDE; O14207; -.
DR EnsemblFungi; SPAC6B12.02c.1; SPAC6B12.02c.1:pep; SPAC6B12.02c.
DR GeneID; 2543237; -.
DR KEGG; spo:SPAC6B12.02c; -.
DR PomBase; SPAC6B12.02c; mus7.
DR VEuPathDB; FungiDB:SPAC6B12.02c; -.
DR eggNOG; ENOG502QSDS; Eukaryota.
DR HOGENOM; CLU_236057_0_0_1; -.
DR InParanoid; O14207; -.
DR OMA; GDILQYC; -.
DR PRO; PR:O14207; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0035361; C:Cul8-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IGI:PomBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:PomBase.
DR GO; GO:0031297; P:replication fork processing; IMP:PomBase.
DR InterPro; IPR019021; Mms22.
DR PANTHER; PTHR28122; PTHR28122; 1.
DR Pfam; PF09462; Mus7; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..1888
FT /note="Protein mms22"
FT /id="PRO_0000116662"
FT REGION 12..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1888 AA; 217434 MW; 8AD3BBCE32397C29 CRC64;
MNSFLLLDHV SDSQDSGSEW SNTHGSLISQ RGNEYDGITP ATKEKNQNKL EILNNETTIG
STKSSVSSLP ELNRNVSFEK SDQNLAETKR EEENKRTEVF KKDAEHEAVV VKRDFRPRRP
EQTRPYTYDF LRHQIEFKRI GLVPITVPHG FSSDRSITSK SSHKPVNVIV RNRASSRKPP
LTSTHRFRRY GAVISDSDDD ESNTEQDHSK ESNLNTADND LALSSTIEGK KTSTSKEALE
SESLLSDSDQ SMTNISSNST VSDLNLKTLK KRLRGVLPPS FLTLQEKKKL ENRGVKKKTS
LHKSVIEGEK IKGVARRKLH PRSTAKLSSE LGNEISDSDN SISTPTPTDD SRFDTSEFLD
SISRDNGWLK EDVVDQLWLP KRSLSALKKS SSLTSENPFQ LNVAANAVST IPVYRTTKTK
MKKNRFKYVE VEKLPDLILE SYGKKAPKFL RVFARSSSHI PKMIRRKRQM DSKKYFSFDK
ESDRQVIDQV LSDWYSGKHE LVQQSHSYKK PSDSKSVGGN IFSVNSKKHS VNINAKTAAN
NGLSHLQNFS EELLKKRKLF SSLFSNNVSY KKSKKLKRTH TVHDKCQKVA KLDHYIRDNI
ELNSKEREHD CYEGTLAVPQ VNTEIRKSSR KQKAQRFIRD DFDTVFFQSS SNPNYFTDVN
PFWNIGIWST TFNVITFRPG LSLPNNSFIK TQGLNSILQL DIVTHPFKSV YAFSCLFNIQ
DDVFKTFEKL KDTFETVLEN LPYFTNSETV DLYNLLSFCS AFILHSQVSM GLVNLASSFL
ETYALVNDRV SSISGLNRSQ LVEKIAVLFQ TFQVVFYCEF ELGNQQNINK VSWLASDLIS
KLLSAGQSGL LECYRNLRIQ ASDTTVIDTL FLESWSILNH ILFHVYKKKY ALWEQVNSFF
DLQKKELSIL EMEKIWYVIM TLNPVFQIGL NGTTHSPGNN SFWPLIIRVS ESAFKMHKDG
HNVKVVERYL RTVFLRIHFL ISEWRWEDVA QILFLIFDFF SHRKFNDLSS EISEDTPTDF
PDFVKSLDRP PNLHVTALDT CFVIYLKVIL ISISRLRQVD ENTNSIKRIV SRLQPLHSRQ
YTRESPFSIK DFMSLEHTHT LLICLYWAAP ENCRPSLNRI RDIVIVDNSH LKARLISLKA
WLHLMKYVIK EGTDYELAQG MEWFNSILKV TFDEYLALFS NGTSVGEMQL AEYSKHQLEN
ALIVAFHSLQ DLIPNSSVYI SRINVLVTEQ SCRRILKDSH FFPPRVTLEC ILFLKKFLQY
QSNTEPPKVT VVGSTSHDSQ DAYFDSDVLD DNTLILEQEK FERKYEVAQI LRTFVSPFLY
QTISYLVGND EDKENYIRIL LLPLMECMAI CASFAVEAKI NDWSYYIDFG SESWERIRNT
PLKRSLSTTF YSFLISYNDS FIKKHEEKVL TVWFESLGAL DEDHAAQFTI LLLQKNLKNP
ILLNLPISVK IEEISINYFK SVHLNLLTAV FCNMAKLYAD AKTNGFASSQ YLQSLFIHYL
SSLLSSMQHS YETNGHSSDT HSLFVINSQR VVGDILQYCS QFANDRNLPA LRYFMDSTKF
PQPPERLEYT ALRLRSYARK TLTNSASQNA LFSFLKANFD VALLEQKQTE TSNLLRLAMG
FHNQNSSSKW DVEISSLRKF CVKELLLSYL GEGSLAAMFY SLLLLEGLSR TYNSFRRIYL
QPYIQQLLCE EISVFVADLE KYALLYENKR PLLSGRIYYL ISSFVAISMT NKTSGLPSSL
ICNLQNFLAR IARDFLLELC WNIEGSEFPP PYNTVDCRSK FVKTIQQHCS ADWYDNVTNI
VHKSRKKKLV LPSQVEQEEE YWSGLMEVTI QIWKHDKGFL EPELDRFLNV ICSYAPDMSG
LPTKIKCFLD KIGYSWMTEE NDFDIVLF
