MMS36_MAGGM
ID MMS36_MAGGM Reviewed; 347 AA.
AC Q6NE78; V6F540;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Probable magnetosome protein Mms36 {ECO:0000305};
GN Name=mms36 {ECO:0000303|PubMed:24816605}; OrderedLocusNames=MGMSRv2__2398;
GN ORFNames=mgI458, MGR_4071, ORF2 {ECO:0000303|PubMed:13129949};
OS Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271
OS / MSR-1).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Magnetospirillum.
OX NCBI_TaxID=431944;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=13129949; DOI=10.1128/jb.185.19.5779-5790.2003;
RA Schuebbe S., Kube M., Scheffel A., Wawer C., Heyen U., Meyerdierks A.,
RA Madkour M.H., Mayer F., Reinhardt R., Schueler D.;
RT "Characterization of a spontaneous nonmagnetic mutant of Magnetospirillum
RT gryphiswaldense reveals a large deletion comprising a putative magnetosome
RT island.";
RL J. Bacteriol. 185:5779-5790(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=16237001; DOI=10.1128/jb.187.21.7176-7184.2005;
RA Ullrich S., Kube M., Schuebbe S., Reinhardt R., Schueler D.;
RT "A hypervariable 130-kilobase genomic region of Magnetospirillum
RT gryphiswaldense comprises a magnetosome island which undergoes frequent
RT rearrangements during stationary growth.";
RL J. Bacteriol. 187:7176-7184(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=17449609; DOI=10.1128/jb.00119-07;
RA Richter M., Kube M., Bazylinski D.A., Lombardot T., Gloeckner F.O.,
RA Reinhardt R., Schueler D.;
RT "Comparative genome analysis of four magnetotactic bacteria reveals a
RT complex set of group-specific genes implicated in magnetosome
RT biomineralization and function.";
RL J. Bacteriol. 189:4899-4910(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=24625872; DOI=10.1128/genomea.00171-14;
RA Wang X., Wang Q., Zhang W., Wang Y., Li L., Wen T., Zhang T., Zhang Y.,
RA Xu J., Hu J., Li S., Liu L., Liu J., Jiang W., Tian J., Li Y., Schuler D.,
RA Wang L., Li J.;
RT "Complete genome sequence of Magnetospirillum gryphiswaldense MSR-1.";
RL Genome Announc. 2:0-0(2014).
RN [5]
RP PROBABLE OPERON, AND DISRUPTION PHENOTYPE.
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=22043287; DOI=10.1371/journal.pone.0025561;
RA Lohsse A., Ullrich S., Katzmann E., Borg S., Wanner G., Richter M.,
RA Voigt B., Schweder T., Schueler D.;
RT "Functional analysis of the magnetosome island in Magnetospirillum
RT gryphiswaldense: the mamAB operon is sufficient for magnetite
RT biomineralization.";
RL PLoS ONE 6:E25561-E25561(2011).
RN [6]
RP FUNCTION, PROBABLE OPERON, AND DISRUPTION PHENOTYPE.
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=24816605; DOI=10.1128/jb.01716-14;
RA Lohsse A., Borg S., Raschdorf O., Kolinko I., Tompa E., Posfai M.,
RA Faivre D., Baumgartner J., Schueler D.;
RT "Genetic dissection of the mamAB and mms6 operons reveals a gene set
RT essential for magnetosome biogenesis in Magnetospirillum gryphiswaldense.";
RL J. Bacteriol. 196:2658-2669(2014).
CC -!- FUNCTION: The 4 genes of this operon collectively influence magnetosome
CC size and number. {ECO:0000269|PubMed:24816605}.
CC -!- SUBCELLULAR LOCATION: Magnetosome membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000255}.
CC -!- INDUCTION: Part of the probable mms6 operon.
CC {ECO:0000305|PubMed:22043287, ECO:0000305|PubMed:24816605}.
CC -!- DISRUPTION PHENOTYPE: Normal magnetic response, fewer, larger
CC magnetosomes; cells accumulate 20% more iron (PubMed:24816605).
CC Deletion of the 4 gene operon (mms6, mmsF, mms36 and mms48) gives an
CC intermediate magnetic response with fewer, smaller magnetosomes in
CC irregular pseudo-chains (PubMed:22043287, PubMed:24816605). Deletion of
CC approximately 80 kb of DNA, including this gene, leads to cells that
CC are non-magnetic, lack internal membrane systems, grow poorly, have
CC reduced mobility and take-up and accumulate iron poorly
CC (PubMed:13129949). {ECO:0000269|PubMed:13129949,
CC ECO:0000269|PubMed:22043287, ECO:0000269|PubMed:24816605}.
CC -!- MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral
CC magnetosomes of about 45 nm in diameter which contain membrane-bound
CC crystals of magnetite (Fe(3)O(4)). {ECO:0000305|PubMed:13129949}.
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DR EMBL; BX571797; CAE12015.1; -; Genomic_DNA.
DR EMBL; AM085146; CAJ30094.1; -; Genomic_DNA.
DR EMBL; CU459003; CAM78003.1; -; Genomic_DNA.
DR EMBL; HG794546; CDK99613.1; -; Genomic_DNA.
DR RefSeq; WP_024080607.1; NZ_CP027526.1.
DR AlphaFoldDB; Q6NE78; -.
DR SMR; Q6NE78; -.
DR STRING; 1430440.MGMSRv2_2398; -.
DR EnsemblBacteria; CDK99613; CDK99613; MGMSRv2__2398.
DR KEGG; mgy:MGMSRv2__2398; -.
DR HOGENOM; CLU_798778_0_0_5; -.
DR OrthoDB; 871653at2; -.
DR Proteomes; UP000018922; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0110146; C:magnetosome membrane; IEA:UniProtKB-SubCell.
PE 3: Inferred from homology;
KW Biomineralization; Magnetosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Probable magnetosome protein Mms36"
FT /id="PRO_0000447816"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 347 AA; 36376 MW; 02DEA90E6DFD5C2F CRC64;
MDINEKAPGP SGRRPARRRD GGGQVLVLYL AIAVVVAVLA WPWLAPRLGS FPGSLLSWIG
DGGSVGAPRP ATLDERMDMV EAALAPLAMR IAEADRRLAM LEANPRTAGE DPRKEAAGVS
ADPEQMSWMA AEIATLKGDL EIVRKLAADE GGATKLSGAV EKAEAAFRRI AERRDRAPLF
LAALGQLREA VDRGSPYPAQ MKAAMILAEK GTADKLAPLV MGSATGIVTR VGLAESFRVT
AAAARKLDVP ADSGWVPPNI RRWLGGAVLI RRTEGGEEGL DGILNSTSRL LAGGDLAGAA
ALLRRAEGPS LAAIQPWLEA AELRLSADAA LSELSAMAMT VASSRDE
