MMSF_MAGGM
ID MMSF_MAGGM Reviewed; 107 AA.
AC A4U547; V6F2J6;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2019, sequence version 2.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Magnetosome protein MmsF {ECO:0000305};
GN Name=mmsF {ECO:0000303|PubMed:17449609}; OrderedLocusNames=MGMSRv2__2397;
GN ORFNames=MGR_4072;
OS Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271
OS / MSR-1).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Magnetospirillum.
OX NCBI_TaxID=431944;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=17449609; DOI=10.1128/jb.00119-07;
RA Richter M., Kube M., Bazylinski D.A., Lombardot T., Gloeckner F.O.,
RA Reinhardt R., Schueler D.;
RT "Comparative genome analysis of four magnetotactic bacteria reveals a
RT complex set of group-specific genes implicated in magnetosome
RT biomineralization and function.";
RL J. Bacteriol. 189:4899-4910(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=24625872; DOI=10.1128/genomea.00171-14;
RA Wang X., Wang Q., Zhang W., Wang Y., Li L., Wen T., Zhang T., Zhang Y.,
RA Xu J., Hu J., Li S., Liu L., Liu J., Jiang W., Tian J., Li Y., Schuler D.,
RA Wang L., Li J.;
RT "Complete genome sequence of Magnetospirillum gryphiswaldense MSR-1.";
RL Genome Announc. 2:0-0(2014).
RN [3]
RP PROBABLE OPERON, AND DISRUPTION PHENOTYPE.
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=22043287; DOI=10.1371/journal.pone.0025561;
RA Lohsse A., Ullrich S., Katzmann E., Borg S., Wanner G., Richter M.,
RA Voigt B., Schweder T., Schueler D.;
RT "Functional analysis of the magnetosome island in Magnetospirillum
RT gryphiswaldense: the mamAB operon is sufficient for magnetite
RT biomineralization.";
RL PLoS ONE 6:E25561-E25561(2011).
RN [4]
RP SEQUENCE REVISION TO N-TERMINUS, FUNCTION, PROBABLE OPERON, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1;
RX PubMed=24816605; DOI=10.1128/jb.01716-14;
RA Lohsse A., Borg S., Raschdorf O., Kolinko I., Tompa E., Posfai M.,
RA Faivre D., Baumgartner J., Schueler D.;
RT "Genetic dissection of the mamAB and mms6 operons reveals a gene set
RT essential for magnetosome biogenesis in Magnetospirillum gryphiswaldense.";
RL J. Bacteriol. 196:2658-2669(2014).
CC -!- FUNCTION: Plays a role in regulating magnetite crystal size; partially
CC redundant function with MamF. {ECO:0000269|PubMed:24816605}.
CC -!- SUBCELLULAR LOCATION: Magnetosome membrane
CC {ECO:0000250|UniProtKB:Q2W8R4}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Part of the probable mms6 operon.
CC {ECO:0000305|PubMed:22043287, ECO:0000305|PubMed:24816605}.
CC -!- DISRUPTION PHENOTYPE: Intermediate magnetic response, slightly smaller
CC magnetosomes. Double mamF-mmsF and double mms6-mmsF deletions have a
CC normal magnetic response, slightly smaller, fewer magnetosomes
CC (PubMed:24816605). Deletion of the 4 gene operon (mms6, mmsF, mms36 and
CC mms48) gives an intermediate magnetic response with fewer, smaller
CC magnetosomes in irregular pseudo-chains (PubMed:22043287,
CC PubMed:24816605). {ECO:0000269|PubMed:22043287,
CC ECO:0000269|PubMed:24816605}.
CC -!- MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral
CC magnetosomes of about 45 nm in diameter which contain membrane-bound
CC crystals of magnetite (Fe(3)O(4)). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the magnetosome MamF/MmsF protein family.
CC {ECO:0000305|PubMed:24816605}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM78004.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305|PubMed:24816605};
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DR EMBL; CU459003; CAM78004.1; ALT_INIT; Genomic_DNA.
DR EMBL; HG794546; CDK99612.1; -; Genomic_DNA.
DR RefSeq; WP_024080606.1; NZ_CP027526.1.
DR AlphaFoldDB; A4U547; -.
DR STRING; 1430440.MGMSRv2_2397; -.
DR EnsemblBacteria; CDK99612; CDK99612; MGMSRv2__2397.
DR KEGG; mgry:MSR1_03170; -.
DR KEGG; mgy:MGMSRv2__2397; -.
DR eggNOG; COG4818; Bacteria.
DR HOGENOM; CLU_095018_0_1_5; -.
DR OrthoDB; 1823639at2; -.
DR Proteomes; UP000018922; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0110146; C:magnetosome membrane; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Biomineralization; Magnetosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..107
FT /note="Magnetosome protein MmsF"
FT /id="PRO_0000447797"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..46
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..107
FT /note="Lumenal"
FT /evidence="ECO:0000305"
SQ SEQUENCE 107 AA; 11986 MW; 57D280EAA1A6BCB0 CRC64;
MVEAILRSTL GARTTVMAAL SYLSVLCFVP LLVDRDDEFV YFHAKQGLVI WMWGVLALFA
LHVPVLGKWI FGFSSMGVLV FSLLGLVSVV FQRAWKLPVV SWVADRI
