ID   MMSR_PSEAE              Reviewed;         307 AA.
AC   P28809;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   08-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=MmsAB operon regulatory protein {ECO:0000305};
GN   Name=mmsR {ECO:0000303|PubMed:1339433}; OrderedLocusNames=PA3571;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=1339433; DOI=10.1016/s0021-9258(18)42252-1;
RA   Steele M.I., Lorenz D., Hatter K., Park A., Sokatch J.R.;
RT   "Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO
RT   encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate
RT   dehydrogenase.";
RL   J. Biol. Chem. 267:13585-13592(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Regulatory protein for the mmsAB operon. Activates the
CC       transcription of the mmsAB genes. {ECO:0000269|PubMed:1339433}.
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DR   EMBL; M84911; AAA25890.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06959.1; -; Genomic_DNA.
DR   PIR; A42902; A42902.
DR   PIR; F83198; F83198.
DR   RefSeq; NP_252261.1; NC_002516.2.
DR   RefSeq; WP_003122160.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; P28809; -.
DR   SMR; P28809; -.
DR   STRING; 287.DR97_4368; -.
DR   PaxDb; P28809; -.
DR   EnsemblBacteria; AAG06959; AAG06959; PA3571.
DR   GeneID; 878815; -.
DR   KEGG; pae:PA3571; -.
DR   PATRIC; fig|208964.12.peg.3737; -.
DR   PseudoCAP; PA3571; -.
DR   HOGENOM; CLU_000445_88_6_6; -.
DR   InParanoid; P28809; -.
DR   OMA; WEYFWIS; -.
DR   PhylomeDB; P28809; -.
DR   BioCyc; PAER208964:G1FZ6-3639-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:2000284; P:positive regulation of cellular amino acid biosynthetic process; IMP:PseudoCAP.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..307
FT                   /note="MmsAB operon regulatory protein"
FT                   /id="PRO_0000194539"
FT   DOMAIN          201..299
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        218..239
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        266..289
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   CONFLICT        129
FT                   /note="S -> T (in Ref. 1; AAA25890)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   307 AA;  35379 MW;  9BF7AEE348FAFD45 CRC64;
     MDYIAEPATD MSHTSDWPLP ADSLRLPIPA ALLEKLAVHP LSRDLYPTSL GHYRRARDHR
     MSRERHDEHL LIYCSEGQGL LRVREGEAWR EYRVGSGDLL WLPPGMAHDY AADDRQPWTI
     FWTHLRGDSA TWLQHSAGYR DTPLRHWGLQ HALLGGFEQL LEVRHSGYRF QHFLLAASRL
     RSLLCQLPLL RPLREGSLDL DGLHAYMREH LHARLELERL AAFCNLSKFH FVSRYKAITG
     RTPIQHFLHL KIEYACQLLD SSDQSVARVG QAVGYDDSYY FSRLFSKVMG LSPSAYRQRV
     RQGEGGA