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MMT1_YEAST
ID   MMT1_YEAST              Reviewed;         510 AA.
AC   Q03218; D6W000; Q66R35;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Mitochondrial metal transporter 1;
DE   Flags: Precursor;
GN   Name=MMT1; Synonyms=MFT1; OrderedLocusNames=YMR177W; ORFNames=YM8010.07;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=9353309; DOI=10.1074/jbc.272.45.28485;
RA   Li L., Kaplan J.;
RT   "Characterization of two homologous yeast genes that encode mitochondrial
RT   iron transporters.";
RL   J. Biol. Chem. 272:28485-28493(1997).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   FUNCTION.
RX   PubMed=15107423; DOI=10.1074/jbc.m402795200;
RA   Jensen L.T., Sanchez R.J., Srinivasan C., Valentine J.S., Culotta V.C.;
RT   "Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes
RT   and oxidative stress relevant to Cu,Zn superoxide dismutase.";
RL   J. Biol. Chem. 279:29938-29943(2004).
CC   -!- FUNCTION: Mitochondrial metal transporter involved in mitochondrial
CC       iron accumulation. {ECO:0000269|PubMed:15107423,
CC       ECO:0000269|PubMed:9353309}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000269|PubMed:9353309}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:9353309}.
CC   -!- MISCELLANEOUS: Present with 6490 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; Z49808; CAA89910.1; -; Genomic_DNA.
DR   EMBL; AY723854; AAU09771.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10074.1; -; Genomic_DNA.
DR   PIR; S55124; S55124.
DR   RefSeq; NP_013902.1; NM_001182683.1.
DR   AlphaFoldDB; Q03218; -.
DR   BioGRID; 35355; 53.
DR   DIP; DIP-4694N; -.
DR   IntAct; Q03218; 1.
DR   STRING; 4932.YMR177W; -.
DR   MaxQB; Q03218; -.
DR   PaxDb; Q03218; -.
DR   PRIDE; Q03218; -.
DR   EnsemblFungi; YMR177W_mRNA; YMR177W; YMR177W.
DR   GeneID; 855215; -.
DR   KEGG; sce:YMR177W; -.
DR   SGD; S000004789; MMT1.
DR   VEuPathDB; FungiDB:YMR177W; -.
DR   eggNOG; KOG1485; Eukaryota.
DR   GeneTree; ENSGT00940000176753; -.
DR   HOGENOM; CLU_013430_12_2_1; -.
DR   InParanoid; Q03218; -.
DR   OMA; GVYFHSQ; -.
DR   BioCyc; YEAST:G3O-32865-MON; -.
DR   PRO; PR:Q03218; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03218; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IMP:SGD.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   1: Evidence at protein level;
KW   Ion transport; Iron; Iron storage; Iron transport; Membrane; Mitochondrion;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix;
KW   Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..510
FT                   /note="Mitochondrial metal transporter 1"
FT                   /id="PRO_0000203318"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          120..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        408
FT                   /note="S -> P (in Ref. 3; AAU09771)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   510 AA;  56209 MW;  F3CC9A230FB5DB87 CRC64;
     MLRICVKRPC IKIVLSQVRP ALLVRKENLH ISTGVKVEKS SIINQKDPNK VRVEINELKR
     QAEIEKAAIK ELEKNPQYQK LAEAFNSHDH VHLRESETEQ NDIISLGTIR DYKSSKCEQA
     DKPSSLNLHS HTHSHGHTHS HAAHNPLLVL STEQIRKNAG VRITWVGLGV NVGIAIGKFF
     GGIVFHSQAL FADAIHAISD MVSDLLTLLS VGLAANKPTA DYPYGYGKIE TVGSLAVSTI
     LAMAGISIGW SSLCALVGPV IPHTIIDTIG NLGHAHTYSE DIIEDVTDIN AAWIAAASIA
     AKEWIFRATR KIAINTNSNV LMANAWHHRV DSLTSLVALV AISTGYLVNI QSLDTIGGLI
     VSGLIIKAGG EGMCIAIKEL IDQSVSRDDP RYLEIETLVK DTLNKLISNN NSQKPYGLKE
     LTLLSSGPNL RGHLTLEVPL QKWGNILGVN EFEIVTHHLR NVLTNEVSNL RRLDIEYVEE
     KNGEENEHIK GQQNYKEDVL IKHDHTNTHI
 
 
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