MMUP_ECOLI
ID MMUP_ECOLI Reviewed; 467 AA.
AC Q47689;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Probable S-methylmethionine permease;
GN Name=mmuP; Synonyms=ykfD; OrderedLocusNames=b0260, JW5027;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT - 6.0 min (189,987 - 281,416bp) region.";
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP POSSIBLE FUNCTION.
RX PubMed=9882684; DOI=10.1128/jb.181.2.662-665.1999;
RA Thanbichler M., Neuhierl B., Boeck A.;
RT "S-methylmethionine metabolism in Escherichia coli.";
RL J. Bacteriol. 181:662-665(1999).
CC -!- FUNCTION: Transporter for the intake of S-methylmethionine.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB08681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U70214; AAB08681.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC73363.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA77928.2; -; Genomic_DNA.
DR PIR; D64751; D64751.
DR RefSeq; NP_414794.4; NC_000913.3.
DR RefSeq; WP_001393629.1; NZ_LN832404.1.
DR AlphaFoldDB; Q47689; -.
DR SMR; Q47689; -.
DR BioGRID; 4259776; 11.
DR STRING; 511145.b0260; -.
DR TCDB; 2.A.3.1.10; the amino acid-polyamine-organocation (apc) family.
DR jPOST; Q47689; -.
DR PaxDb; Q47689; -.
DR PRIDE; Q47689; -.
DR EnsemblBacteria; AAC73363; AAC73363; b0260.
DR EnsemblBacteria; BAA77928; BAA77928; BAA77928.
DR GeneID; 946284; -.
DR KEGG; ecj:JW5027; -.
DR KEGG; eco:b0260; -.
DR PATRIC; fig|511145.12.peg.263; -.
DR EchoBASE; EB3126; -.
DR eggNOG; COG0833; Bacteria.
DR HOGENOM; CLU_007946_9_2_6; -.
DR InParanoid; Q47689; -.
DR OMA; QIVFRRR; -.
DR PhylomeDB; Q47689; -.
DR BioCyc; EcoCyc:B0260-MON; -.
DR BioCyc; MetaCyc:B0260-MON; -.
DR PRO; PR:Q47689; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0000100; F:S-methylmethionine transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0009086; P:methionine biosynthetic process; IMP:EcoCyc.
DR GO; GO:0015806; P:S-methylmethionine transport; IMP:EcoCyc.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR Pfam; PF00324; AA_permease; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..467
FT /note="Probable S-methylmethionine permease"
FT /id="PRO_0000054205"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 50526 MW; E7ADB9A3B03C10F8 CRC64;
MQTTQQNAPL KRTMKTRHLI MLSLGGVIGT GLFFNTGYII STTGAAGTLL AYLIGALVVW
LVMQCLGELS VAMPETGAFH VYAARYLGPA TGYTVAWLYW LTWTVALGSS FTAAGFCMQY
WFPQVPVWVW CVVFCAIIFG LNVISTRFFA EGEFWFSLVK VVTIIAFIIL GGAAIFGFIP
MQDGSPAPGL SNITAEGWFP HGGLPILMTM VAVNFAFSGT ELIGIAAGET ENPRKVIPVA
IRTTIARLII FFIGTVFVLA ALIPMQQVGV EKSPFVLVFE KVGIPYAADI FNFVILTAIL
SAANSGLYAS GRMLWSLSNE RTLPACFARV TKNGVPLTAL SVSMLGGVLA LFSSVVAPDT
VFVALSAISG FAVVAVWLSI CASHFVFRRR HLQQGKALSE LHYRAPWYPL VPVLGFVLCL
VACVGLAFDP AQRIALWCGL PFVALCYGAY FLTQPRNAKQ EPEHVAE
