MNAR1_RAT
ID MNAR1_RAT Reviewed; 917 AA.
AC D3ZJ47;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 3.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Major intrinsically disordered Notch2-binding receptor 1;
DE AltName: Full=Membrane integral NOTCH2-associated receptor 1;
DE AltName: Full=Ubiquitination and mTOR signaling protein {ECO:0000303|PubMed:30080879};
GN Name=Minar1; Synonyms=Ubtor {ECO:0000303|PubMed:30080879};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP FUNCTION, AND INDUCTION BY NGF.
RX PubMed=30080879; DOI=10.1371/journal.pgen.1007583;
RA Zhang H., Zhang Q., Gao G., Wang X., Wang T., Kong Z., Wang G., Zhang C.,
RA Wang Y., Peng G.;
RT "UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR
RT signaling.";
RL PLoS Genet. 14:E1007583-E1007583(2018).
CC -!- FUNCTION: Intrinsically disordered protein which may negatively
CC regulate mTOR signaling pathway by stabilizing the mTOR complex
CC component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis
CC (By similarity). Negatively regulates cell growth (By similarity).
CC Negatively regulates neurite outgrowth in hippocampal neurons
CC (PubMed:30080879). {ECO:0000250|UniProtKB:Q9UPX6,
CC ECO:0000269|PubMed:30080879}.
CC -!- SUBUNIT: Interacts with NOTCH2; this interaction increases MINAR1
CC stability. Interacts (via N-terminus) with DEPTOR (via PDZ domain);
CC this interaction may stabilize DEPTOR protein by impairing its
CC ubiquitination. {ECO:0000250|UniProtKB:Q9UPX6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UPX6};
CC Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9UPX6}.
CC -!- INDUCTION: Up-regulated by NGF. {ECO:0000269|PubMed:30080879}.
CC -!- SIMILARITY: Belongs to the MINAR family. {ECO:0000305}.
CC -!- CAUTION: MINAR1 topology is a matter of debate, some authors think the
CC N-terminus is extracellular, while preliminary experimental results
CC suggest a cytosolic location. {ECO:0000250|UniProtKB:Q9UPX6}.
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DR EMBL; AABR07071020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001055454.1; XM_001055454.5.
DR RefSeq; XP_001066296.1; XM_001066296.5.
DR RefSeq; XP_017451604.1; XM_017596115.1.
DR RefSeq; XP_017451605.1; XM_017596116.1.
DR RefSeq; XP_017459188.1; XM_017603699.1.
DR RefSeq; XP_017459189.1; XM_017603700.1.
DR AlphaFoldDB; D3ZJ47; -.
DR SMR; D3ZJ47; -.
DR iPTMnet; D3ZJ47; -.
DR PhosphoSitePlus; D3ZJ47; -.
DR PaxDb; D3ZJ47; -.
DR PRIDE; D3ZJ47; -.
DR Ensembl; ENSRNOT00000018553; ENSRNOP00000018553; ENSRNOG00000013399.
DR GeneID; 501033; -.
DR UCSC; RGD:1591930; rat.
DR CTD; 23251; -.
DR RGD; 1591930; Minar1.
DR eggNOG; ENOG502QSCS; Eukaryota.
DR GeneTree; ENSGT00530000063851; -.
DR HOGENOM; CLU_016692_0_0_1; -.
DR InParanoid; D3ZJ47; -.
DR OrthoDB; 1321736at2759; -.
DR TreeFam; TF350677; -.
DR PRO; PR:D3ZJ47; -.
DR Proteomes; UP000002494; Chromosome 8.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:RGD.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IMP:UniProtKB.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IMP:UniProtKB.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IMP:UniProtKB.
DR InterPro; IPR039706; MINAR1-like.
DR InterPro; IPR009626; MINAR1-like_C.
DR PANTHER; PTHR31530; PTHR31530; 1.
DR Pfam; PF06789; MINAR1_C; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..917
FT /note="Major intrinsically disordered Notch2-binding
FT receptor 1"
FT /id="PRO_0000445579"
FT TOPO_DOM 1..892
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 893..913
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 914..917
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT REGION 337..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 712
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K3V7"
SQ SEQUENCE 917 AA; 102819 MW; 3F089E77F1D6F0FA CRC64;
MEANQEASLF LVKILEELDS KQNTVSYQDL CKSLCAQFDL SQLAKLRSVL FYTACLDPNF
PATLFKDKMK CSVNNQQSKK IMVAADIVTI FNLIQMNGGT AKEKLPTSCH KVRKEEASFE
SCRSDAEVCS PTVCEPLNCE LSERPFSRGY PTRQSSKCRK MDCKECPQFV PASEPNFLLG
VSKEVKNRAA SLDRLQALSP YSVASPQPCE MQRTYFPMNI ENESISDQDS LPIGQGIKET
FISSEEPFMV QSCVQKRNIF KEDFHNLMTV SPSLVGTTNK AEEDHGEPRS QKELHKPPFF
NHSFEMPYHS QYLNPVYSPI PDKRRAKHES LDDLQASTYF GPTPVMGTQD TRRCPGRPSK
QTPWPAKSWS LNTEEVPDFE RSFFNRNPSE EKLRYPNSGN QTPNFSGPDR HPVYLVPKDQ
QKVLPAGYAV KPNGLKSKEI PSPVDLEKHE AVKKFKDKSI SCTSGQHSSD TSSVGTQTEQ
HVLDPPKCKD LCSAGQAKYS DRHAMKHSDD DSEIVSDDIS DIFRFLDDMS ISGSTGVIQS
SCYNSTGSLS QLHKSDCDSS PEHNLAKITN GVSGSKGDKC NRPENVHHSE EELKSSVCKL
VLRIGEIERK LESLAGVREE ISQVLGKLNK LDQKIQQPEK VNVQIDLNSL TSEAPSDDSA
SPRVFHAHSG SHGPKLENSP DWCCSDVSGS NSESLRVKAL KKSLFTRPSS RSLTEENSAT
ESKIASISNS PRDWRTITYT NRMSLNEEEI KDAGPANNKD WHRKSKEADR QYDIPPQHRL
PKQPKDGFLV EQVFSPHPYP SSLKAHMKSN PLYTDMRLTE LAEVKRGQPS WNIEEYARNT
GDKGKLTALD LQTQESLNPN NLEYWMEDIY TPGYDSLLKR KEAEFRRAKV CKIAALITAA
ACTVILVIVV PICTMKS
