MNARL_MOUSE
ID MNARL_MOUSE Reviewed; 193 AA.
AC Q8C4X7; A0A0R4J0Q0; E9Q5J6; Q6DI98;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2018, sequence version 4.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Major intrinsically disordered NOTCH2-binding receptor 1-like homolog;
DE AltName: Full=Membrane integral NOTCH2-associated receptor 2 {ECO:0000312|MGI:MGI:2442934};
GN Name=Minar2 {ECO:0000312|MGI:MGI:2442934};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C4X7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C4X7-2; Sequence=VSP_059939;
CC -!- SIMILARITY: Belongs to the MINAR family. {ECO:0000305}.
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DR EMBL; AK080452; BAC37921.1; -; mRNA.
DR EMBL; AC132242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466528; EDL09843.1; -; Genomic_DNA.
DR EMBL; CH466528; EDL09844.1; -; Genomic_DNA.
DR EMBL; BC075669; AAH75669.1; -; mRNA.
DR CCDS; CCDS29267.2; -. [Q8C4X7-1]
DR RefSeq; NP_776120.3; NM_173759.5. [Q8C4X7-1]
DR RefSeq; XP_006525941.1; XM_006525878.3. [Q8C4X7-2]
DR AlphaFoldDB; Q8C4X7; -.
DR SMR; Q8C4X7; -.
DR STRING; 10090.ENSMUSP00000125952; -.
DR iPTMnet; Q8C4X7; -.
DR PhosphoSitePlus; Q8C4X7; -.
DR SwissPalm; Q8C4X7; -.
DR jPOST; Q8C4X7; -.
DR PRIDE; Q8C4X7; -.
DR ProteomicsDB; 333102; -.
DR ProteomicsDB; 357308; -.
DR Antibodypedia; 2707; 6 antibodies from 6 providers.
DR DNASU; 225583; -.
DR Ensembl; ENSMUST00000058633; ENSMUSP00000056379; ENSMUSG00000050875. [Q8C4X7-2]
DR Ensembl; ENSMUST00000118510; ENSMUSP00000113023; ENSMUSG00000050875. [Q8C4X7-2]
DR Ensembl; ENSMUST00000165666; ENSMUSP00000125952; ENSMUSG00000050875. [Q8C4X7-1]
DR Ensembl; ENSMUST00000175830; ENSMUSP00000135330; ENSMUSG00000050875. [Q8C4X7-2]
DR GeneID; 225583; -.
DR KEGG; mmu:225583; -.
DR CTD; 100127206; -.
DR MGI; MGI:2442934; Minar2.
DR VEuPathDB; HostDB:ENSMUSG00000050875; -.
DR eggNOG; ENOG502RZQB; Eukaryota.
DR GeneTree; ENSGT00530000063851; -.
DR HOGENOM; CLU_120056_0_0_1; -.
DR InParanoid; Q8C4X7; -.
DR OMA; YPAAQHW; -.
DR OrthoDB; 1321736at2759; -.
DR PhylomeDB; Q8C4X7; -.
DR BioGRID-ORCS; 225583; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q8C4X7; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8C4X7; protein.
DR Bgee; ENSMUSG00000050875; Expressed in optic fissure and 172 other tissues.
DR ExpressionAtlas; Q8C4X7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039706; MINAR1-like.
DR InterPro; IPR009626; MINAR1-like_C.
DR PANTHER; PTHR31530; PTHR31530; 1.
DR Pfam; PF06789; MINAR1_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..193
FT /note="Major intrinsically disordered NOTCH2-binding
FT receptor 1-like homolog"
FT /id="PRO_0000157136"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747"
FT VAR_SEQ 1..59
FT /note="MKGDMDLSVLPNNNHPDKFLQLDVKSLMRSSTLLQASLARFPGGNYPATQHW
FT QNLVYSQ -> MPAYQEDREEDTCTIGE (in isoform 2)"
FT /id="VSP_059939"
FT CONFLICT 158
FT /note="K -> E (in Ref. 1; BAC37921)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 193 AA; 21854 MW; 920D21B969685367 CRC64;
MKGDMDLSVL PNNNHPDKFL QLDVKSLMRS STLLQASLAR FPGGNYPATQ HWQNLVYSQR
EKTIATQRIK GFGVENPVLP ESPPASMSSV MKNNPLYGDI TLEEAMEERK KSPSWTIEEY
DKHSVHTNLS GHLKENPNDL RFWLGDTYTP GFDTLLKKKK KRNKRSKLCH MGLILLLVAS
ILVTIVTLST IFS
