ID   MNCP_OXYTR              Reviewed;         371 AA.
AC   Q27151; Q94633;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Macronuclear solute carrier homolog CR-MSC;
OS   Oxytricha trifallax (Sterkiella histriomuscorum).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Sterkiella.
OX   NCBI_TaxID=94289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JRB310;
RX   PubMed=8952079; DOI=10.1093/oxfordjournals.molbev.a025581;
RA   Seegmiller A., Williams K.R., Hammersmith R.L., Doak T.G., Witherspoon D.,
RA   Messick T., Storjohann L.L., Herrick G.;
RT   "Internal eliminated sequences interrupting the Oxytricha 81 locus: allelic
RT   divergence, conservation, conversions, and possible transposon origins.";
RL   Mol. Biol. Evol. 13:1351-1362(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 4-371.
RX   PubMed=1909784; DOI=10.1093/nar/19.17.4717;
RA   Williams K.R., Herrick G.;
RT   "Expression of the gene encoded by a family of macronuclear chromosomes
RT   generated by alternative DNA processing in Oxytricha fallax.";
RL   Nucleic Acids Res. 19:4717-4724(1991).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; L20237; AAA75394.1; -; Genomic_DNA.
DR   EMBL; M63174; AAA62489.1; -; mRNA.
DR   AlphaFoldDB; Q27151; -.
DR   SMR; Q27151; -.
DR   PRIDE; Q27151; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..371
FT                   /note="Macronuclear solute carrier homolog CR-MSC"
FT                   /id="PRO_0000090710"
FT   TRANSMEM        22..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          16..111
FT                   /note="Solcar 1"
FT   REPEAT          120..208
FT                   /note="Solcar 2"
FT   REPEAT          215..304
FT                   /note="Solcar 3"
FT   CONFLICT        96
FT                   /note="G -> C (in Ref. 2; AAA62489)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        168
FT                   /note="V -> I (in Ref. 2; AAA62489)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        262
FT                   /note="F -> I (in Ref. 2; AAA62489)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        354
FT                   /note="A -> T (in Ref. 2; AAA62489)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        366
FT                   /note="D -> E (in Ref. 2; AAA62489)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   371 AA;  42548 MW;  40E2471DB927E6E4 CRC64;
     MPTQMEVEYW RRRYQRMNYE RFAAANVIAL ITHAATQPLD MVRIRSQMLQ EGKTFSGLGY
     QKGWYPFQIM EEIYAAGGGL RKFYSAFDTF FFRTVGYTTA RVTAFGYFYD KVNKDPRRVA
     RPDFLVAAGV LGGFIAGVVT NPIDIVYNRM QVDELYPQAA RRNYSNTVQG LAKVAEEGAL
     FRGAGANGFK LAAICSSMTN IYDWCKENSY FFFGPHWINR LWGTAVAVAI GTVVSMPFDM
     IRTRLHTMRP LPNGQMPYNG MFDCFNKIIK YECNSKWMSN FGSFYAGGEA YFLRLFLICY
     LSQFLVDYYN ENYYDQEFWQ PQRFHYQSGI DYDIHDPYTD AFNKKLVATY TTAAGGMGAA
     HPSGKDNLAI I