MND1_ARATH
ID MND1_ARATH Reviewed; 230 AA.
AC Q8GYD2; A8MS27; Q9SZE5;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Meiotic nuclear division protein 1 homolog;
DE Short=AtMND1;
DE AltName: Full=Meiotic nuclear division 1-like protein;
GN Name=MND1; OrderedLocusNames=At4g29170; ORFNames=F19B15.200;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=16442857; DOI=10.1016/j.dnarep.2005.12.007;
RA Domenichini S., Raynaud C., Ni D.A., Henry Y., Bergounioux C.;
RT "Atmnd1-delta1 is sensitive to gamma-irradiation and defective in meiotic
RT DNA repair.";
RL DNA Repair 5:455-464(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH HOP2,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=16763194; DOI=10.1242/jcs.02967;
RA Kerzendorfer C., Vignard J., Pedrosa-Harand A., Siwiec T., Akimcheva S.,
RA Jolivet S., Sablowski R., Armstrong S., Schweizer D., Mercier R.,
RA Schloegelhofer P.;
RT "The Arabidopsis thaliana MND1 homologue plays a key role in meiotic
RT homologous pairing, synapsis and recombination.";
RL J. Cell Sci. 119:2486-2496(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=16872528; DOI=10.1186/1471-2199-7-24;
RA Panoli A.P., Ravi M., Sebastian J., Nishal B., Reddy T.V., Marimuthu M.P.,
RA Subbiah V., Vijaybhaskar V., Siddiqi I.;
RT "AtMND1 is required for homologous pairing during meiosis in Arabidopsis.";
RL BMC Mol. Biol. 7:24-24(2006).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOP2; LIM15 AND RAD51.
RX PubMed=17937504; DOI=10.1371/journal.pgen.0030176;
RA Vignard J., Siwiec T., Chelysheva L., Vrielynck N., Gonord F.,
RA Armstrong S.J., Schloegelhofer P., Mercier R.;
RT "The interplay of RecA-related proteins and the MND1-HOP2 complex during
RT meiosis in Arabidopsis thaliana.";
RL PLoS Genet. 3:1894-1906(2007).
RN [9]
RP INTERACTION WITH MIP1.
RX PubMed=19187040; DOI=10.1111/j.1365-313x.2009.03814.x;
RA Dean P.J., Siwiec T., Waterworth W.M., Schloegelhofer P., Armstrong S.J.,
RA West C.E.;
RT "A novel ATM dependant X-ray inducible gene is essential for both plant
RT meiosis and gametogenesis.";
RL Plant J. 58:791-802(2009).
CC -!- FUNCTION: Required for proper homologous chromosome pairing and
CC efficient cross-over and intragenic recombination during meiosis.
CC Stimulates both DMC1/LIM15- and RAD51-mediated homologous strand
CC assimilation, which is required for the resolution of meiotic double-
CC strand breaks. {ECO:0000269|PubMed:16763194,
CC ECO:0000269|PubMed:16872528, ECO:0000269|PubMed:17937504}.
CC -!- SUBUNIT: Interacts with HOP2, RAD51, LIM15 and MIP1.
CC {ECO:0000269|PubMed:16763194, ECO:0000269|PubMed:17937504,
CC ECO:0000269|PubMed:19187040}.
CC -!- INTERACTION:
CC Q8GYD2; Q9ZNV8: AHP2; NbExp=2; IntAct=EBI-1554720, EBI-1100687;
CC Q8GYD2; Q39009: DMC1; NbExp=2; IntAct=EBI-1554720, EBI-307715;
CC Q8GYD2; Q8RX22: MIP1; NbExp=2; IntAct=EBI-1554720, EBI-2270543;
CC Q8GYD2; P94102: RAD51; NbExp=2; IntAct=EBI-1554720, EBI-307687;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17937504}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:17937504}. Note=Localized to chromatin
CC during meiosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8GYD2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8GYD2-2; Sequence=VSP_037490;
CC -!- TISSUE SPECIFICITY: Expressed in reproductive tissues.
CC {ECO:0000269|PubMed:16872528}.
CC -!- DISRUPTION PHENOTYPE: Female and male sterility due to production of
CC defective gametes. {ECO:0000269|PubMed:16763194,
CC ECO:0000269|PubMed:16872528}.
CC -!- SIMILARITY: Belongs to the MND1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB43931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79675.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AM162278; CAJ44238.1; -; mRNA.
DR EMBL; DQ248000; ABB73190.1; -; mRNA.
DR EMBL; AL078470; CAB43931.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161574; CAB79675.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85596.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85597.1; -; Genomic_DNA.
DR EMBL; AK117713; BAC42364.1; -; mRNA.
DR EMBL; BT005435; AAO63855.1; -; mRNA.
DR PIR; T08972; T08972.
DR RefSeq; NP_001078469.1; NM_001085000.2. [Q8GYD2-2]
DR RefSeq; NP_194646.2; NM_119061.4. [Q8GYD2-1]
DR AlphaFoldDB; Q8GYD2; -.
DR SMR; Q8GYD2; -.
DR BioGRID; 14325; 9.
DR IntAct; Q8GYD2; 6.
DR STRING; 3702.AT4G29170.1; -.
DR iPTMnet; Q8GYD2; -.
DR PaxDb; Q8GYD2; -.
DR PRIDE; Q8GYD2; -.
DR ProteomicsDB; 238293; -. [Q8GYD2-1]
DR EnsemblPlants; AT4G29170.1; AT4G29170.1; AT4G29170. [Q8GYD2-1]
DR EnsemblPlants; AT4G29170.2; AT4G29170.2; AT4G29170. [Q8GYD2-2]
DR GeneID; 829038; -.
DR Gramene; AT4G29170.1; AT4G29170.1; AT4G29170. [Q8GYD2-1]
DR Gramene; AT4G29170.2; AT4G29170.2; AT4G29170. [Q8GYD2-2]
DR KEGG; ath:AT4G29170; -.
DR Araport; AT4G29170; -.
DR TAIR; locus:2119881; AT4G29170.
DR eggNOG; KOG3433; Eukaryota.
DR HOGENOM; CLU_080628_3_0_1; -.
DR InParanoid; Q8GYD2; -.
DR OMA; VCYWAFP; -.
DR PhylomeDB; Q8GYD2; -.
DR PRO; PR:Q8GYD2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8GYD2; baseline and differential.
DR Genevisible; Q8GYD2; AT.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006302; P:double-strand break repair; IMP:TAIR.
DR GO; GO:0009553; P:embryo sac development; IMP:TAIR.
DR GO; GO:0009555; P:pollen development; IMP:TAIR.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR GO; GO:0010212; P:response to ionizing radiation; IMP:TAIR.
DR InterPro; IPR040661; LZ3wCH.
DR InterPro; IPR005647; Mnd1.
DR InterPro; IPR040453; Mnd1_HTH.
DR Pfam; PF18517; LZ3wCH; 1.
DR Pfam; PF03962; Mnd1; 1.
DR PIRSF; PIRSF026991; Mnd1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA recombination; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..230
FT /note="Meiotic nuclear division protein 1 homolog"
FT /id="PRO_0000377432"
FT COILED 79..146
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..15
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_037490"
SQ SEQUENCE 230 AA; 26403 MW; 131BB5146D8C91ED CRC64;
MSKKRGLSLE EKREKMLQIF YESQDFFLLK ELEKMGPKKG VISQSVKDVI QSLVDDDLVA
KDKIGISIYF WSLPSCAGNQ LRSVRQKLES DLQGSNKRLA ELVDQCEALK KGREESEERT
EALTQLKDIE KKHKDLKNEM VQFADNDPAT LEAKRNAIEV AHQSANRWTD NIFTLRQWCS
NNFPQAKEQL EHLYTEAGIT EDFDYIELSS FPLSSSHEAD TAKQLVQDEA
