MND1_HUMAN
ID MND1_HUMAN Reviewed; 205 AA.
AC Q9BWT6; B2R5F9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Meiotic nuclear division protein 1 homolog;
GN Name=MND1 {ECO:0000312|EMBL:EAX04964.1};
GN Synonyms=GAJ {ECO:0000312|EMBL:AAK26168.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAK26168.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Solis G., Hofer H.W.;
RT "GAJ protein isolated from Jurkat cells.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3] {ECO:0000312|EMBL:AAK26168.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH32142.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph {ECO:0000312|EMBL:AAH32142.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH PSMC3IP.
RX PubMed=16407260; DOI=10.1074/jbc.m506506200;
RA Enomoto R., Kinebuchi T., Sato M., Yagi H., Kurumizaka H., Yokoyama S.;
RT "Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex.";
RL J. Biol. Chem. 281:5575-5581(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Required for proper homologous chromosome pairing and
CC efficient cross-over and intragenic recombination during meiosis (By
CC similarity). Stimulates both DMC1- and RAD51-mediated homologous strand
CC assimilation, which is required for the resolution of meiotic double-
CC strand breaks. {ECO:0000250|UniProtKB:Q8K396,
CC ECO:0000269|PubMed:16407260}.
CC -!- SUBUNIT: Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with
CC DMC1 and RAD51 and binds preferentially to dsDNA.
CC {ECO:0000250|UniProtKB:Q8K396, ECO:0000269|PubMed:16407260}.
CC -!- INTERACTION:
CC Q9BWT6; Q9P2W1: PSMC3IP; NbExp=5; IntAct=EBI-11137441, EBI-9057595;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MND1 family. {ECO:0000305}.
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DR EMBL; AY028916; AAK26168.1; -; mRNA.
DR EMBL; AK312172; BAG35106.1; -; mRNA.
DR EMBL; CH471056; EAX04964.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX04965.1; -; Genomic_DNA.
DR EMBL; BC032142; AAH32142.1; -; mRNA.
DR CCDS; CCDS3782.1; -.
DR RefSeq; NP_115493.1; NM_032117.3.
DR AlphaFoldDB; Q9BWT6; -.
DR SMR; Q9BWT6; -.
DR BioGRID; 123852; 58.
DR ComplexPortal; CPX-6661; HOP2-MND1 complex.
DR CORUM; Q9BWT6; -.
DR IntAct; Q9BWT6; 7.
DR STRING; 9606.ENSP00000240488; -.
DR iPTMnet; Q9BWT6; -.
DR PhosphoSitePlus; Q9BWT6; -.
DR BioMuta; MND1; -.
DR DMDM; 74733462; -.
DR EPD; Q9BWT6; -.
DR jPOST; Q9BWT6; -.
DR MassIVE; Q9BWT6; -.
DR MaxQB; Q9BWT6; -.
DR PaxDb; Q9BWT6; -.
DR PeptideAtlas; Q9BWT6; -.
DR PRIDE; Q9BWT6; -.
DR ProteomicsDB; 79314; -.
DR Antibodypedia; 27871; 164 antibodies from 23 providers.
DR DNASU; 84057; -.
DR Ensembl; ENST00000240488.8; ENSP00000240488.3; ENSG00000121211.8.
DR GeneID; 84057; -.
DR KEGG; hsa:84057; -.
DR MANE-Select; ENST00000240488.8; ENSP00000240488.3; NM_032117.4; NP_115493.1.
DR UCSC; uc003ink.3; human.
DR CTD; 84057; -.
DR DisGeNET; 84057; -.
DR GeneCards; MND1; -.
DR HGNC; HGNC:24839; MND1.
DR HPA; ENSG00000121211; Tissue enhanced (bone marrow, lymphoid tissue, testis).
DR MIM; 611422; gene.
DR neXtProt; NX_Q9BWT6; -.
DR OpenTargets; ENSG00000121211; -.
DR PharmGKB; PA143485544; -.
DR VEuPathDB; HostDB:ENSG00000121211; -.
DR eggNOG; KOG3433; Eukaryota.
DR GeneTree; ENSGT00490000043413; -.
DR HOGENOM; CLU_080628_3_1_1; -.
DR InParanoid; Q9BWT6; -.
DR OMA; VCYWAFP; -.
DR OrthoDB; 880961at2759; -.
DR PhylomeDB; Q9BWT6; -.
DR TreeFam; TF314068; -.
DR PathwayCommons; Q9BWT6; -.
DR Reactome; R-HSA-912446; Meiotic recombination.
DR SignaLink; Q9BWT6; -.
DR BioGRID-ORCS; 84057; 17 hits in 1089 CRISPR screens.
DR ChiTaRS; MND1; human.
DR GenomeRNAi; 84057; -.
DR Pharos; Q9BWT6; Tbio.
DR PRO; PR:Q9BWT6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9BWT6; protein.
DR Bgee; ENSG00000121211; Expressed in ventricular zone and 97 other tissues.
DR ExpressionAtlas; Q9BWT6; baseline and differential.
DR Genevisible; Q9BWT6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IDA:ComplexPortal.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IDA:ComplexPortal.
DR InterPro; IPR040661; LZ3wCH.
DR InterPro; IPR005647; Mnd1.
DR InterPro; IPR040453; Mnd1_HTH.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF18517; LZ3wCH; 1.
DR Pfam; PF03962; Mnd1; 1.
DR PIRSF; PIRSF026991; Mnd1; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; DNA recombination; DNA-binding; Meiosis; Nucleus;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..205
FT /note="Meiotic nuclear division protein 1 homolog"
FT /id="PRO_0000318081"
FT COILED 84..173
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 205 AA; 23753 MW; 95B0B14068DA0B51 CRC64;
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV LQSLVDDGMV
DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH ASLQKSIEKA KIGRCETEER
TRLAKELSSL RDQREQLKAE VEKYKDCDPQ VVEEIRQANK VAKEAANRWT DNIFAIKSWA
KRKFGFEENK IDRTFGIPED FDYID
