MND1_YEAST
ID MND1_YEAST Reviewed; 219 AA.
AC P53102; D6VTX1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Meiotic nuclear division protein 1;
GN Name=MND1; OrderedLocusNames=YGL183C; ORFNames=G1604;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9046087;
RX DOI=10.1002/(sici)1097-0061(199701)13:1<55::aid-yea48>3.0.co;2-9;
RA Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V.;
RT "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII
RT from Saccharomyces cerevisiae.";
RL Yeast 13:55-64(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP PROTEIN SEQUENCE OF 1-5, FUNCTION, INTERACTION WITH HOP2, AND DNA-BINDING.
RX PubMed=15249670; DOI=10.1073/pnas.0404195101;
RA Chen Y.-K., Leng C.-H., Olivares H., Lee M.-H., Chang Y.-C., Kung W.-M.,
RA Ti S.-C., Lo Y.-H., Wang A.H.-J., Chang C.-S., Bishop D.K., Hsueh Y.-P.,
RA Wang T.-F.;
RT "Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote
RT meiotic homolog juxtaposition and strand assimilation.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:10572-10577(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-219.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP REVISION OF GENE MODEL, FUNCTION, INTERACTION WITH HOP2, AND SUBCELLULAR
RP LOCATION.
RX PubMed=11940665; DOI=10.1128/mcb.22.9.3078-3088.2002;
RA Tsubouchi H., Roeder G.S.;
RT "The Mnd1 protein forms a complex with Hop2 to promote homologous
RT chromosome pairing and meiotic double-strand break repair.";
RL Mol. Cell. Biol. 22:3078-3088(2002).
RN [7]
RP REVISION OF GENE MODEL, AND FUNCTION.
RX PubMed=12011448; DOI=10.1073/pnas.102167899;
RA Gerton J.L., DeRisi J.L.;
RT "Mnd1p: an evolutionarily conserved protein required for meiotic
RT recombination.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:6895-6900(2002).
RN [8]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15120066; DOI=10.1016/j.cub.2004.04.030;
RA Zierhut C., Berlinger M., Rupp C., Shinohara A., Klein F.;
RT "Mnd1 is required for meiotic interhomolog repair.";
RL Curr. Biol. 14:752-762(2004).
CC -!- FUNCTION: Required for proper homologous chromosome pairing and
CC efficient cross-over and intragenic recombination during meiosis.
CC Stimulates DMC1-dependent homologous strand assimilation, which is
CC required for the resolution of meiotic double-strand breaks.
CC {ECO:0000269|PubMed:11940665, ECO:0000269|PubMed:12011448,
CC ECO:0000269|PubMed:15120066, ECO:0000269|PubMed:15249670}.
CC -!- SUBUNIT: Heterodimer with HOP2. MND1-HOP2 binds preferentially to
CC dsDNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11940665,
CC ECO:0000269|PubMed:15120066}.
CC -!- SIMILARITY: Belongs to the MND1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA62791.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA96895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X91489; CAA62791.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z72704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z72705; CAA96895.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY558488; AAS56814.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07932.1; -; Genomic_DNA.
DR PIR; S61134; S61134.
DR RefSeq; NP_011332.2; NM_001181048.1.
DR AlphaFoldDB; P53102; -.
DR SMR; P53102; -.
DR BioGRID; 33072; 31.
DR ComplexPortal; CPX-1644; HOP2-MND1 complex.
DR DIP; DIP-2673N; -.
DR IntAct; P53102; 2.
DR MINT; P53102; -.
DR STRING; 4932.YGL183C; -.
DR PaxDb; P53102; -.
DR PRIDE; P53102; -.
DR TopDownProteomics; P53102; -.
DR EnsemblFungi; YGL183C_mRNA; YGL183C; YGL183C.
DR GeneID; 852692; -.
DR KEGG; sce:YGL183C; -.
DR SGD; S000003151; MND1.
DR VEuPathDB; FungiDB:YGL183C; -.
DR eggNOG; KOG3433; Eukaryota.
DR GeneTree; ENSGT00490000043413; -.
DR HOGENOM; CLU_080628_2_0_1; -.
DR InParanoid; P53102; -.
DR OMA; VCYWAFP; -.
DR BioCyc; YEAST:G3O-30669-MON; -.
DR PRO; PR:P53102; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53102; protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:SGD.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IDA:ComplexPortal.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IDA:ComplexPortal.
DR InterPro; IPR040661; LZ3wCH.
DR InterPro; IPR005647; Mnd1.
DR InterPro; IPR040453; Mnd1_HTH.
DR Pfam; PF18517; LZ3wCH; 1.
DR Pfam; PF03962; Mnd1; 1.
DR PIRSF; PIRSF026991; Mnd1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; DNA recombination; DNA-binding;
KW Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..219
FT /note="Meiotic nuclear division protein 1"
FT /id="PRO_0000096522"
FT COILED 88..181
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 26083 MW; C81729B2AC8018E0 CRC64;
MGPKRQTVSL QEKKNRILNF FQETYTFYNI KELEKSIPKK CGISPMIVKD LVQQMIDEDG
VISVEKCGNI NIYWCFKNQT LQKLYDSSEL IKKKIQEVKC DIATYKQELD KTLATGRRKK
FTVGQKSYNR EALLEKRKKI QDEIKKKSNS LQKIESIRWD AAKIQENKQQ IRLKKVHLEK
TTDNIEILID YLYKKFFLKP EQIRKEFGIP EEFKEFTEV
