MNDAL_MOUSE
ID MNDAL_MOUSE Reviewed; 538 AA.
AC D0QMC3; D0QMC4;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Myeloid cell nuclear differentiation antigen-like protein {ECO:0000303|PubMed:19654412};
GN Name=Mndal {ECO:0000303|PubMed:19654412};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ACT83572.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, INDUCTION, POLYMORPHISM, AND VARIANTS ASN-6; ASP-58; GLY-100;
RP ARG-131; MET-245; SER-297; GLU-324; LEU-339; THR-436; 438-ASN--LYS-440;
RP ILE-443; VAL-456; ARG-459; SER-483; ILE-496 AND ASP-523.
RC STRAIN=BALB/cAn {ECO:0000312|EMBL:ACT83573.1}, and
RC C57BL/6J {ECO:0000312|EMBL:ACT83572.1};
RC TISSUE=Spleen {ECO:0000312|EMBL:ACT83573.1};
RX PubMed=19654412; DOI=10.1182/blood-2009-01-198812;
RA Zhang K., Kagan D., DuBois W., Robinson R., Bliskovsky V., Vass W.C.,
RA Zhang S., Mock B.A.;
RT "Mndal, a new interferon-inducible family member, is highly polymorphic,
RT suppresses cell growth, and may modify plasmacytoma susceptibility.";
RL Blood 114:2952-2960(2009).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- FUNCTION: Suppresses cell growth when expressed ectopically.
CC {ECO:0000269|PubMed:19654412}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19654412}.
CC -!- TISSUE SPECIFICITY: Highest expression observed in spleen and thymus
CC with moderate levels in bone marrow, lung, skin and heart, low levels
CC in muscle, liver and intestine and little or no expression in brain and
CC pancreas. {ECO:0000269|PubMed:19654412}.
CC -!- INDUCTION: By interferon-alpha and interferon-beta.
CC {ECO:0000269|PubMed:19654412}.
CC -!- POLYMORPHISM: This gene is present in strains 129/J, 129/SvJ, BALB/cAn,
CC BALB/cJ, BALB/cHeA, CBA/N, C3H/HeJ, C3H/HeN, C57BL/6J, C57BL/10SnJ,
CC C57L/J, NOD and NZW/LacJ but is absent in strains 129S6/SvEvTac, AKR/N,
CC A/J, DBA/2J, NON, NZB/BlNJ, P/J, SENCARA/Pt, SWR/J and STS/A.
CC {ECO:0000269|PubMed:19654412}.
CC -!- SIMILARITY: Belongs to the HIN-200 family. {ECO:0000255}.
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DR EMBL; FJ594740; ACT83572.1; -; mRNA.
DR EMBL; FJ594741; ACT83573.1; -; mRNA.
DR EMBL; AC170584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48452.1; -.
DR RefSeq; NP_001164324.1; NM_001170853.1.
DR RefSeq; XP_011237034.1; XM_011238732.1.
DR RefSeq; XP_011237035.1; XM_011238733.2.
DR AlphaFoldDB; D0QMC3; -.
DR SMR; D0QMC3; -.
DR STRING; 10090.ENSMUSP00000140610; -.
DR iPTMnet; D0QMC3; -.
DR PhosphoSitePlus; D0QMC3; -.
DR SwissPalm; D0QMC3; -.
DR EPD; D0QMC3; -.
DR jPOST; D0QMC3; -.
DR MaxQB; D0QMC3; -.
DR PaxDb; D0QMC3; -.
DR PeptideAtlas; D0QMC3; -.
DR PRIDE; D0QMC3; -.
DR ProteomicsDB; 290268; -.
DR Ensembl; ENSMUST00000188804; ENSMUSP00000140610; ENSMUSG00000090272.
DR GeneID; 100040462; -.
DR KEGG; mmu:100040462; -.
DR UCSC; uc007drz.2; mouse.
DR CTD; 100040462; -.
DR MGI; MGI:3780953; Mndal.
DR VEuPathDB; HostDB:ENSMUSG00000090272; -.
DR eggNOG; ENOG502QTQS; Eukaryota.
DR GeneTree; ENSGT00390000013296; -.
DR InParanoid; D0QMC3; -.
DR OMA; CHDIRCE; -.
DR OrthoDB; 1304994at2759; -.
DR PhylomeDB; D0QMC3; -.
DR TreeFam; TF337385; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 100040462; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Mndal; mouse.
DR PRO; PR:D0QMC3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; D0QMC3; protein.
DR Bgee; ENSMUSG00000090272; Expressed in peripheral lymph node and 151 other tissues.
DR ExpressionAtlas; D0QMC3; baseline and differential.
DR Genevisible; D0QMC3; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0002218; P:activation of innate immune response; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; ISO:MGI.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISO:MGI.
DR GO; GO:0035458; P:cellular response to interferon-beta; IBA:GO_Central.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; ISO:MGI.
DR GO; GO:0030308; P:negative regulation of cell growth; IMP:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 2.40.50.140; -; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200; PTHR12200; 2.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 1: Evidence at protein level;
KW Growth regulation; Nucleus; Reference proteome.
FT CHAIN 1..538
FT /note="Myeloid cell nuclear differentiation antigen-like
FT protein"
FT /id="PRO_0000391681"
FT DOMAIN 1..87
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 299..499
FT /note="HIN-200"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00106"
FT REGION 120..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 6
FT /note="K -> N (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 58
FT /note="Y -> D (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 100
FT /note="V -> G (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 131
FT /note="G -> R (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 245
FT /note="R -> M (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 297
FT /note="P -> S (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 324
FT /note="D -> E (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 339
FT /note="F -> L (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 436
FT /note="K -> T (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 438..440
FT /note="KTQ -> NRK (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 443
FT /note="S -> I (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 456
FT /note="E -> V (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 459
FT /note="G -> R (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 483
FT /note="R -> S (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 496
FT /note="V -> I (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
FT VARIANT 523
FT /note="N -> D (in strain: BALB/cAn)"
FT /evidence="ECO:0000269|PubMed:19654412"
SQ SEQUENCE 538 AA; 60526 MW; 8544CC5807221A4C CRC64;
MAEYKKIVLL KGLESMEDYQ FRTVKSLLRK ELKLTKKLQE DYDRIQLADW MEDKFPKYAG
LDKLIKVCEH IKDLKDLAKK LKTEKAKVQK KKQGKCKTAV KKKGQDELSS SESLFINKES
YKSVPSSKKK GKAIAKTEGE KKNKLTQDQD HLPETSGTDI KTEEDCLQNS PKPPPTSPSS
SSNKKKRKEI TKTEGGKKKK LTQEQAQLPE PLGTDIKKDE DCLQTPPKPP PTPPSSSLNK
KRKSRREEET GVKKSKAAKE PDQPPCCEEP TARCQSPILH SSSSASSNIP SATNQKPQPQ
NQNIPRGAVL HSEPLTVMVL TATDPFEYES PEHEVKNMFH ATVATVSQYF HVKVFNINLK
EKFTKKNFII ISNYFESKGI LEINETSSVL KADPDQMIEV PNNIIRNANA SPKICDIQKG
TSGAVFYGVF TLHKKKVKTQ NTSYEIKDGS GSIEVEGSGQ WHNINCKEGD KLHLFCFHLK
RERGQPKLVC GDHSFVKIKV TKAGKKKEAS TVLSSTKNEE ENNYPKDGIK VEMPDYHV
