ID   MNDA_MACFA              Reviewed;         407 AA.
AC   Q8SPH9;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Myeloid cell nuclear differentiation antigen;
GN   Name=MNDA; ORFNames=QnpA-13106;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RX   PubMed=11991714; DOI=10.1006/geno.2002.6753;
RA   Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S., Hirai M.,
RA   Hashimoto K.;
RT   "Search for genes positively selected during primate evolution by 5'-end-
RT   sequence screening of cynomolgus monkey cDNAs.";
RL   Genomics 79:657-662(2002).
CC   -!- FUNCTION: May act as a transcriptional activator/repressor in the
CC       myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific
CC       response to interferon. Stimulates the DNA binding of the
CC       transcriptional repressor protein YY1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Participates in a ternary complex with YY1 and the YY1 target
CC       DNA element. Binds nucleolin and nucleophosmin/NPM/B23 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Uniformly distributed throughout the interphase cell nucleus.
CC       Associates with chromatin (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: Its N-terminal half (200 amino acids) is sufficient for maximum
CC       enhancement of YY1 DNA binding and a portion of this sequence is
CC       responsible for binding YY1. {ECO:0000250}.
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DR   EMBL; AB072022; BAB86811.1; -; mRNA.
DR   RefSeq; NP_001272183.1; NM_001285254.1.
DR   AlphaFoldDB; Q8SPH9; -.
DR   SMR; Q8SPH9; -.
DR   STRING; 9541.XP_005541379.1; -.
DR   PRIDE; Q8SPH9; -.
DR   GeneID; 102132204; -.
DR   CTD; 4332; -.
DR   eggNOG; ENOG502QTQS; Eukaryota.
DR   OrthoDB; 1304994at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR   GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR040205; HIN-200.
DR   InterPro; IPR004021; HIN200/IF120x.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR12200; PTHR12200; 1.
DR   Pfam; PF02760; HIN; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50834; HIN_200; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..407
FT                   /note="Myeloid cell nuclear differentiation antigen"
FT                   /id="PRO_0000153725"
FT   DOMAIN          1..88
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT   DOMAIN          196..394
FT                   /note="HIN-200"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00106"
FT   REGION          122..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           131..137
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        130..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  45931 MW;  0D7CF22D96050CE8 CRC64;
     MANEYKKILL LKGLELMDEY HFIIIKSLLA YDLGLTTKMQ EEYNRIKISD LMEKKFQGVA
     CVDKLIELAK DMPPLKNLVN NLRKERSKVA RKMKAQGVVL MKKINQEEVG LVAPAPTARN
     TLTSEVGERI PVAQKRKTLS KGKTEAKRIK VPQEQSEPPH PSGASTSAAT DHPPLPHTSS
     STPSNTSFAQ NQQTQAQCQV DTRRNVPQKD PVTVMVLKAT APFKYESPEH GKSTMFHATV
     ASKTQYFHVK VFDISLKEKF IRKKVITISD YSECKGVMEI KEASSVSDFD QNFEVPNRII
     EIANKTPKIS QLYKQASGTM VYGLFMVQKK SIHKKNTIYE IKDNTGSMDV VGNGKWHNIK
     CEKGDKLRLF CFQLRTVNRK LKLVCGSHSF IKVIKAKKNK EGSMNVN