MNEA_VIBC3
ID MNEA_VIBC3 Reviewed; 200 AA.
AC A0A0H3AJF5;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 1.
DT 25-MAY-2022, entry version 21.
DE RecName: Full=Putative manganese exporter {ECO:0000303|PubMed:27481926};
DE AltName: Full=Manganese exporter A {ECO:0000303|PubMed:27481926};
GN Name=mneA {ECO:0000303|PubMed:27481926};
GN OrderedLocusNames=VC0395_A2497 {ECO:0000312|EMBL:ABQ20671.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=27481926; DOI=10.1128/jb.00215-16;
RA Fisher C.R., Wyckoff E.E., Peng E.D., Payne S.M.;
RT "Identification and characterization of a putative manganese export protein
RT in Vibrio cholerae.";
RL J. Bacteriol. 198:2810-2817(2016).
CC -!- FUNCTION: Involved in manganese homeostasis. May function as a
CC manganese exporter. {ECO:0000269|PubMed:27481926}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- INDUCTION: Induced by manganese. {ECO:0000269|PubMed:27481926}.
CC -!- DISRUPTION PHENOTYPE: Mutant exhibits sensitivity to manganese but not
CC to other cations. Under high-manganese conditions, the mutant
CC accumulates high levels of intracellular manganese with a concomitant
CC decrease in intracellular iron levels. Mutant also shows a small, but
CC significant, increase in resistance to oxidative stress induced by
CC hydrogen peroxide. {ECO:0000269|PubMed:27481926}.
CC -!- MISCELLANEOUS: Expression of mneA suppresses the manganese sensitivity
CC of an E.coli mntP mutant. {ECO:0000269|PubMed:27481926}.
CC -!- SIMILARITY: Belongs to the GDT1 family. {ECO:0000305}.
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DR EMBL; CP000627; ABQ20671.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H3AJF5; -.
DR STRING; 345073.VC395_0158; -.
DR EnsemblBacteria; ABQ20671; ABQ20671; VC0395_A2497.
DR KEGG; vco:VC0395_A2497; -.
DR PATRIC; fig|345073.21.peg.149; -.
DR eggNOG; COG2119; Bacteria.
DR OMA; PDKMDDD; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001727; Gdt1.
DR PANTHER; PTHR12608; PTHR12608; 2.
DR Pfam; PF01169; UPF0016; 2.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Ion transport; Manganese; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..200
FT /note="Putative manganese exporter"
FT /id="PRO_0000439587"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 200 AA; 21380 MW; 3EA177A445F7B6DE CRC64;
MFVYGSIINP CPTEHVMSVL AISITTVALA EIGDKTQLLS LLLASRYRKP IPIIAAIFLA
TLANHALAAW LGVVVADYLS PDILKWVLVV SFLTMAGWIL IPDKLDGEES ISTRGPFVAS
FIAFFMAEIG DKTQIATSIL GAQYADALSW VIVGTTLGML LANVPVVLIG KLSADKMPLG
LIRKVTAGLF LLMALATAFF
