MNHA1_STAA9
ID MNHA1_STAA9 Reviewed; 801 AA.
AC A5IRD0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Na(+)/H(+) antiporter subunit A1;
DE AltName: Full=Mnh complex subunit A1;
GN Name=mnhA1; OrderedLocusNames=SaurJH9_0952;
OS Staphylococcus aureus (strain JH9).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=359786;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JH9;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Tomasz A., Richardson P.;
RT "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT JH9.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000250}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; CP000703; ABQ48753.1; -; Genomic_DNA.
DR RefSeq; WP_000054612.1; NC_009487.1.
DR AlphaFoldDB; A5IRD0; -.
DR SMR; A5IRD0; -.
DR KEGG; saj:SaurJH9_0952; -.
DR HOGENOM; CLU_007100_2_1_9; -.
DR OMA; AFILQYM; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005451; F:monovalent cation:proton antiporter activity; IEA:InterPro.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MbhD-like_TM.
DR InterPro; IPR005663; MrpA/MnhA1/PhaAB.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF13244; DUF4040; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR00940; 2a6301s01; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..801
FT /note="Na(+)/H(+) antiporter subunit A1"
FT /id="PRO_0000372095"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 671..691
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 707..727
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 764..784
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 801 AA; 89362 MW; A33A062349FD709F CRC64;
MSLLHIAVIL PLIFALIIPI LYRFFKRIHL GWFVLPVPIV IFIYMLTLIK TTMSGNTVMK
TLNWMPHFGM NFDLYLDGLG LLFSLLISGI GSLVVLYSIG YLSKSEQLGN FYCYLLLFMG
AMLGVVLSDN VIILYLFWEL TSFSSFLLIS FWRERQASIY GAQKSLIITV FGGLSLLGGI
ILLAIPTQSF SIQYMIQHAS EIQNSPFFIF AMILIMIGAF TKSAQFPFYI WLPDAMEAPT
PVSAYLHSAT MVKAGLYLIA RMTPIFAASQ GWVWTVTLVG LITLFWASLN ATKQQDLKGI
LAFSTVSQLG MIMAMLGIGA ISYHYQGDDS KIYAAAFTAA IFHLINHATF KGALFMITGA
VDHSTGTRDV KKLGGLLTIM PISFTITVIT ALSMAGVPPF NGFLSKESFL ETTFTASQAN
LFSVDTLGYL FPIIGIVGSV FTFVYSIKFI MHIFFGQYKP EQLPKKAHEV SILMLLSPAI
LATLVIVLGL FPGILTNSII EPATSSINHT VIDDVEFHMF HGLTPAFLST LVIYILGILL
IVTFSYWVKL LQRQPGKLTF NYWYNRSANV IPNYSEKMTN SYVTDYSRNN LVIIFGALIL
LTFVTIFSVP FNINFKDVSP IRIFEVCIVI LLLSAAFLIL FAKSRLFSII MLSAVGYAVS
VLFIFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN EKRSFQLTNA LIAGGVGLSV
IIIGLIAYGN RHFESISKFY QEHVYDLAHG KNMVNVILVD FRGMDTLFES SVLGIAGLAV
YTMIKLRKKR QTQGNEVKNH E