MNHA1_STAES
ID MNHA1_STAES Reviewed; 801 AA.
AC Q8CPU8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Na(+)/H(+) antiporter subunit A1;
DE AltName: Full=Mnh complex subunit A1;
GN Name=mnhA1; OrderedLocusNames=SE_0646;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000250}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; AE015929; AAO04243.1; -; Genomic_DNA.
DR RefSeq; NP_764201.1; NC_004461.1.
DR RefSeq; WP_001832516.1; NZ_WBME01000044.1.
DR AlphaFoldDB; Q8CPU8; -.
DR SMR; Q8CPU8; -.
DR STRING; 176280.SE_0646; -.
DR EnsemblBacteria; AAO04243; AAO04243; SE_0646.
DR GeneID; 50019207; -.
DR KEGG; sep:SE_0646; -.
DR PATRIC; fig|176280.10.peg.619; -.
DR eggNOG; COG1009; Bacteria.
DR eggNOG; COG2111; Bacteria.
DR HOGENOM; CLU_007100_2_1_9; -.
DR OMA; AFILQYM; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005451; F:monovalent cation:proton antiporter activity; IEA:InterPro.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MbhD-like_TM.
DR InterPro; IPR005663; MrpA/MnhA1/PhaAB.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF13244; DUF4040; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR00940; 2a6301s01; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..801
FT /note="Na(+)/H(+) antiporter subunit A1"
FT /id="PRO_0000372101"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 671..691
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 707..727
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 764..784
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 801 AA; 88781 MW; CE204541D7D503D1 CRC64;
MSLLHIAVLL PLIFALIIPF LYRFVKRIHL GWFVLPVPIV LFIYFISLIS MTMSGNNVMK
NLNWMPHIGM NFNLYVDGLG LLFSLLITGI GSLVVLYSIG YLSKSEQLGN FYCYLLLFMG
AMLGVVLSDN FIILYLFWEL TSFSSFLLIS FWREKKASIY GAQKSLIITV LGGLSMLGGI
ILLSLATDTF SIQAMISKAS DIQNSPFFIL VMILFMIGAF TKSAQVPFYI WLPDAMEAPT
PVSAYLHSAT MVKAGLYLIA RITPIFAISE GWVWTITLVG LITLFWASLN ATKQHDLKGI
LAFSTVSQLG MIMSMLGIGA VSYHYQGANS QLYVAGFVAA IFHLINHATF KGALFMITGG
IDHSTGTRDV KKLGGLLTIM PISFTLTVIT TLSMAGVPPF NGFLSKEKFL ESMINVTHLN
LMSLNTLGIL LPIIAIIGSI FTFVYSIKFI LHIFFGSYKP EALPKQAHES SILMLISPII
LTSLVIVFGL FPSILTQSII EPASVAVSQT SNITAEFHLF HGITPAFLST IGIYIIGILL
LISFSYWVRL LQAHPYQLTL NHWYDTSGQR IPGYSENITN SYVTGFSRNN LVIILGILIA
LTFVTVISVP FSIDFKNVSH LRVFEGATVL FLLIASTFII FAKSRLFSII MLSAVGYAIS
VLFIFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN EKPTFKLTNA VISIGVGLSV
IILGLIGYGN RHFDSITKFY QEHVFDLAHG KNMVNVILVD FRGMDTLFES SVLGIAGLGV
YTMIKLRLKQ KNQSSEVNDH E
