ID   MNHA1_STAHJ             Reviewed;         803 AA.
AC   Q4L4W7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Na(+)/H(+) antiporter subunit A1;
DE   AltName: Full=Mnh complex subunit A1;
GN   Name=mnhA1; OrderedLocusNames=SH1999;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC       family. {ECO:0000305}.
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DR   EMBL; AP006716; BAE05308.1; -; Genomic_DNA.
DR   RefSeq; WP_011276266.1; NC_007168.1.
DR   AlphaFoldDB; Q4L4W7; -.
DR   SMR; Q4L4W7; -.
DR   STRING; 279808.SH1999; -.
DR   EnsemblBacteria; BAE05308; BAE05308; SH1999.
DR   KEGG; sha:SH1999; -.
DR   eggNOG; COG1009; Bacteria.
DR   eggNOG; COG2111; Bacteria.
DR   HOGENOM; CLU_007100_2_1_9; -.
DR   OMA; AFILQYM; -.
DR   OrthoDB; 1274678at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005451; F:monovalent cation:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025383; MbhD-like_TM.
DR   InterPro; IPR005663; MrpA/MnhA1/PhaAB.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   Pfam; PF13244; DUF4040; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR00940; 2a6301s01; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..803
FT                   /note="Na(+)/H(+) antiporter subunit A1"
FT                   /id="PRO_0000372103"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        522..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        621..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        671..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        707..727
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        764..784
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   803 AA;  88946 MW;  54CA04B14811B7F2 CRC64;
     MSLLHIAVIL PLIFALIIPI LYRFFKKIHL GWFVLPIPVV LFIYFLSLIS TTQSGNTVIK
     TLNWMPHIGM NFDLYLDGLS ILFSLLITGI GSLVVLYSIG YLSKSEQLGN FYCYLLLFMG
     AMLGVVLSDN LIILYLFWEL TSFSSFLLIS FWREKKASIY GAQKSLIITV FGGLSLLGGF
     ILISLAGDSL SLHELIANAS EIQHSPLFIF AMVLIMLGAF TKSAQVPFYI WLPDAMEAPT
     PVSAYLHSAT MVKAGLYLVA RVTPLFAISQ GWIWTITLVG LITLFWASLN ATKQQDLKGI
     LAFSTVSQLG MIMSMLGIGA VSYHFEGSQS QLYIAGFTAA VFHLVNHATF KGALFMITGA
     VDHVTGTRDV KKLGGLLTIM PISFTITVIT ALSMAGIPPF NGFLSKEKFL EAMIEISHAN
     VFSLDTLGIV FPILAIVGSI FTFVYSIKFI MYIFFGKHQP NALPKKAHEA SILMLLSPII
     LAVLVVVFGL FPGLLTQSIV EPATTAISGM SNVNAEFHLF HGITPAFIST LIIWILGILL
     LLTFSYWIRL LHAQPTRLTL NHWYDSTGKY LPNYSANMTN SYVNGYVRDS LVIIFGMLIV
     VTIVTLLSVP FDFNFKDINN IHIYEIAILI LLIIAAFMVV IAKSRLFSVI MLGVVGYSVS
     VLFVFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN ETRSFKLTNA LISIGVGLVV
     IILGLIAYGN RHFTSIGEYY KAHVYDLAHG KNMVNVILVD FRGMDTLFES SVLGIAGLGV
     YTMIKLRRKH QSSEVKSDEQ AEQ