ID   MNHA1_STAS1             Reviewed;         805 AA.
AC   Q49W91;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Na(+)/H(+) antiporter subunit A1;
DE   AltName: Full=Mnh complex subunit A1;
GN   Name=mnhA1; OrderedLocusNames=SSP1823;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC       family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE18968.1; -; Genomic_DNA.
DR   RefSeq; WP_011303514.1; NZ_MTGA01000039.1.
DR   AlphaFoldDB; Q49W91; -.
DR   SMR; Q49W91; -.
DR   STRING; 342451.SSP1823; -.
DR   EnsemblBacteria; BAE18968; BAE18968; SSP1823.
DR   KEGG; ssp:SSP1823; -.
DR   PATRIC; fig|342451.11.peg.1819; -.
DR   eggNOG; COG1009; Bacteria.
DR   eggNOG; COG2111; Bacteria.
DR   HOGENOM; CLU_007100_2_1_9; -.
DR   OMA; AFILQYM; -.
DR   OrthoDB; 1274678at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005451; F:monovalent cation:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025383; MbhD-like_TM.
DR   InterPro; IPR005663; MrpA/MnhA1/PhaAB.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   Pfam; PF13244; DUF4040; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR00940; 2a6301s01; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..805
FT                   /note="Na(+)/H(+) antiporter subunit A1"
FT                   /id="PRO_0000372104"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        531..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        623..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        671..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        707..727
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        766..786
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   805 AA;  88961 MW;  4F639D33C732C1BE CRC64;
     MSLLHIAVLL PLIFALIIPF VYRFYKRIHL GWFVLPIPVV LFIYFLSYIS TTMSGNTIME
     KANWMPHFGM NFNLYVDGLG LLFSLLITGI GCLIVLYSIS YLSRQEQLGH FYCYLLLFMG
     AMLGLVLSDN LIILYLFWEL TSFSSFLLIS FWRDKQASIY GAQKSMLVTV FGGLSLLGGI
     ILLSIAGGTT SIQELINNAS EIQTSPFFIF SMILVLIGAM TKSAQFPFYV WLPDAMEAPT
     PVSAYLHSAT MVKAGLYLVA RMTPIFAVSQ GWIWTVTAVG LITLFWASLN ATKQQDLKGI
     LAFSTVSQLG MIMAMLGVGA VSFHFEGAES QIYIAAFTAA IFHLINHATF KGALFMITGA
     VDHSTGTRDV KKLGGLLTIM PISFTITLIT SLSMAGIPPF NGFLSKEKFL ESMIEVTNVN
     LFSLDTLGIL IPITAIIGSV FTFVYSIRFI GQIFLGSYKE DKLPKKAHEV SPLMLISPSI
     LAILVIVFGL FPAILSGSII EPAVNAIGQT TNSTAEFHMF HGFTPAFFST LGIYIVGIVL
     IITFSYWIYL LQKQPTKLTI NYWYNKFGDV TPRYSSKFTD TYVTGFTRNN LVIIFASLIV
     IALVTLLVTP FNIDFKDVSA IRPFELIIVV LIITAASMII FAKSRLFSII MASAVGYSVA
     IFFIFFGAPD LALTQFVVES ISTALFLLCF YHLPNLNRHK ETRSFKLVNI VISVGAGIVV
     TVLGLIAYGN RHFGSIAEFY KTHVYDLAHG TNMVNVILVD FRGTDTLFES SVLGIAGLGV
     YTMIKLRAKN DKSDEGGKNV EQTEE