ID   MNHA2_STAA1             Reviewed;         800 AA.
AC   A7WZ76;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative antiporter subunit mnhA2;
DE   AltName: Full=Mrp complex subunit A2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN   Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SAHV_0619;
OS   Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=418127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu3 / ATCC 700698;
RX   PubMed=17954695; DOI=10.1128/aac.00534-07;
RA   Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT   "Mutated response regulator graR is responsible for phenotypic conversion
RT   of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT   resistance to vancomycin-intermediate resistance.";
RL   Antimicrob. Agents Chemother. 52:45-53(2008).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC       family. {ECO:0000305}.
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DR   EMBL; AP009324; BAF77502.1; -; Genomic_DNA.
DR   RefSeq; WP_000060771.1; NC_009782.1.
DR   AlphaFoldDB; A7WZ76; -.
DR   SMR; A7WZ76; -.
DR   KEGG; saw:SAHV_0619; -.
DR   HOGENOM; CLU_007100_2_1_9; -.
DR   OMA; LSFTQFM; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025383; MbhD-like_TM.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   Pfam; PF13244; DUF4040; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..800
FT                   /note="Putative antiporter subunit mnhA2"
FT                   /id="PRO_0000372290"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        595..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        627..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        651..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        676..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        712..732
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        768..788
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   800 AA;  89610 MW;  1252897F1989D260 CRC64;
     MSLVYLLIAI LVIMAMILLM SKRRALAKYA GYIALVAPVI SSIYFLIQIP SVAKLQYLST
     SIPWIKTLDI NLDLRLDGLS LMFSLIISLI GIAVFFYATQ YLSSRKDNLP RFYFYLTLFM
     FSMIGIVLSD NTILMYIFWE LTSVSSFLLI SYWYNNGDSQ FGAIQSFMIT VFGGLALLVG
     FIMLYIMTGT NNITDILGQA DHIKNHGLFI PMIFMFLLGA FTKSAQFPFH IWLPRAMAAP
     TPVSAYLHSA TMVKAGIFLL LRFTPLLGLS NMYIYIVTFV GLITMLFGSI TALKQWDLKG
     ILAYSTISQL GMIMAMVGIG GGYAQHQQDA IASIYVFVLF GALFHLMNHA IFKCALFMGV
     GILDHEAGSR DIRILSGMRQ LFPKMNLVMT IAALSMAGVP FLNGFLSKEM FLDALTQTGQ
     LSQFSLISMI AIVFVGVIAS IFTFTYALYM VKEVFWTKYD SKVFTKKNIH EPWLFSLPSL
     ILMVLVPVIF FVPNIFGKGI IVPALRGVSG GNHQIDPLAP HVSQWHGFNI PLLLTIIIIL
     LGSVLAIKVD WKKVFTGKIR QISVSKGYEM VYRHFEKFAT KRFKRVMQDR LNQYIIMTLG
     IFMIIIGYGY IRIGLPKVHQ LHVSEFGALE IILAIVTVTI GISLIFIRQR LTMVILNGVI
     GFVVTLFFIA MKAPDLALTQ LVVETITTIL FIVSFSRLPN VPRSNANKKR EIIKISVSLL
     MALIVVSLIF ITQQTDGLSS ISDFYLKADK LTGGKNIVNA ILGDFRALDT LFEGLVLIIT
     GLGIYTLLNY QDRRGQDERE