ID   MNHA2_STAAB             Reviewed;         800 AA.
AC   Q2YST2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative antiporter subunit mnhA2;
DE   AltName: Full=Mrp complex subunit A2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN   Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SAB0573;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC       family. {ECO:0000305}.
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DR   EMBL; AJ938182; CAI80261.1; -; Genomic_DNA.
DR   RefSeq; WP_000060763.1; NC_007622.1.
DR   AlphaFoldDB; Q2YST2; -.
DR   SMR; Q2YST2; -.
DR   KEGG; sab:SAB0573; -.
DR   HOGENOM; CLU_007100_2_1_9; -.
DR   OMA; LSFTQFM; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025383; MbhD-like_TM.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   Pfam; PF13244; DUF4040; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..800
FT                   /note="Putative antiporter subunit mnhA2"
FT                   /id="PRO_0000372286"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        595..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        627..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        651..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        676..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        712..732
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        768..788
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   800 AA;  89828 MW;  40EC7596942005F7 CRC64;
     MSLVYLLIAI LVIMAMILLM SKRRALAKYA GYIALIAPVI SSIYFMIQIP SVAKLQYLST
     SIPWIKTLDI NLDLRLDGLS LMFSLIISLI GIAVFFYATQ YLSSRKDNLP RFYFYLTLFM
     FSMIGIVLSD NTILMYIFWE LTSVSSFLLI SYWYNNGDNQ FGAIQSFMIT VFGGLALLVG
     FIMLYIMTGT NNITDILGQA DHIKNHGLFM PMIFMFLLGA FTKSAQFPFH IWLPRAMAAP
     TPVSAYLHSA TMVKAGIFLL LRFTPLLGLS NMYIYIVTFV GLITMLFGSI TALKQWDLKG
     ILAYSTISQL GMIMVMVGIG GGYAQHQQDA IASIYTFVLF GALFHLMNHA IFKCALFMGV
     GILDHEAGSR DIRILSEMRQ LFPKMNLVMT IAALSMAGVP FLNGFLSKEM FLDALTQTGQ
     LSQFSLISMI AIVFVGVIAS VFTFTYALYM VKEVFWTKYD SKVFTKKNIH EPWLFSLPSL
     ILMVLVPVIF FVPNIFGKGI IVPALRAVSA GNHQIDQLAP HVSQWHGFNI PLLLTIIIIL
     LGSVLAIKVD WKKVFTGKIR QISVSKSYEM VYRHFEKFAT KRFKRVMQDR LNQYIIMTLG
     IFMVIIGYGY IRIGLPKVHQ LHVSEFGPLE VILAIVTVTI GISLIFIRQR LTMVILNGVI
     GFVVTLLFIA MKAPDLALTQ LVVETITTIL FIVSFSRLPN VPRSNANKKR EIIKISVSLL
     MALIVVSLIF ITQQTDGLSS ISDFYLKADK LTGGKNIVNA ILGDFRALDT LFEGLVLIIT
     GLGIYTLLNY QDRRGQDERE