MNHA2_STAAR
ID MNHA2_STAAR Reviewed; 800 AA.
AC Q6GJ47;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Putative antiporter subunit mnhA2;
DE AltName: Full=Mrp complex subunit A2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SAR0630;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; BX571856; CAG39648.1; -; Genomic_DNA.
DR RefSeq; WP_000060783.1; NC_002952.2.
DR AlphaFoldDB; Q6GJ47; -.
DR SMR; Q6GJ47; -.
DR KEGG; sar:SAR0630; -.
DR HOGENOM; CLU_007100_2_0_9; -.
DR OMA; LSFTQFM; -.
DR OrthoDB; 1274678at2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MbhD-like_TM.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF13244; DUF4040; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..800
FT /note="Putative antiporter subunit mnhA2"
FT /id="PRO_0000372288"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..615
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 800 AA; 89689 MW; 2DECDC71343F0FC3 CRC64;
MSLVYLLIAI LVIMAMILLT SKRRAMAKYA GYIALTAPVI ASIYFLLQVP SVIKQHYLSV
SIPWMTSLDI NVDLRLDGLS LMFSLIISLI GIAVFFYATQ YLSSRKDNLP RFYLYLTLFM
FSMLGIVLAD NTILMYVFWE LTSVSSFLLI SYWYNNGDSQ FGAMQSFMIT VFGGLALLVG
FIMLYIMTGT NNITEILGQA DHIKNHALFI PMIIMFLLGA FTKSAQFPFH IWLPRAMAAP
TPVSAYLHSA TMVKAGIFLL LRFTPLLGLS NMYIYIVTFV GLITMLFGSI TALKQWDLKG
ILAYSTISQL GMIMAMVGIG GGYAQHQQDA IASIYVFVLF AALFHLMNHA IFKCALFMGV
GILDHEAGSR DIRILSGMRQ LFPKMNLVMM IAALSMAGVP FLNGFLSKEM FLDALTQTGQ
LSQFSLISMI IIVCMGVIAS IFTFTYALYM VKEVFWTKYD SKVFTKKNIH EPWLFSLPSL
ILMVLVPVIF FVPNIFGKGI IVPALRGVSG GNHQIDPLVP HVSQWHGFNI PLLLTIIIIL
LGSVLAIKVD WKKVFTGKIR QISVSKGYEM VYRQFEKFTT KRFKRVMQDR LNQYIIMTLG
IFMVIIGYGY IRIGLPKVHQ LHVSEFGPLE VILAIVTVII GLSLIFIRQR LTMVILNGVI
GFVVTLFFIA MKAPDLALTQ LVVETITTIL FIVSFSRLPN VPRSKVNKKR EIIKISVSLM
MALIVVSLIF IAQQADGLAS ISNFYLRADK LTGGKNIVNA ILGDFRALDT LFEGLVLIIT
GLGIYTLLNY QDRRGQDERE
