MNHA2_STAEQ
ID MNHA2_STAEQ Reviewed; 800 AA.
AC Q5HRB2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Putative antiporter subunit mnhA2;
DE AltName: Full=Mrp complex subunit A2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SERP0281;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; CP000029; AAW53724.1; -; Genomic_DNA.
DR RefSeq; WP_002438805.1; NC_002976.3.
DR AlphaFoldDB; Q5HRB2; -.
DR SMR; Q5HRB2; -.
DR STRING; 176279.SERP0281; -.
DR EnsemblBacteria; AAW53724; AAW53724; SERP0281.
DR GeneID; 50019446; -.
DR KEGG; ser:SERP0281; -.
DR eggNOG; COG1009; Bacteria.
DR eggNOG; COG2111; Bacteria.
DR HOGENOM; CLU_007100_2_1_9; -.
DR OMA; LSFTQFM; -.
DR OrthoDB; 1274678at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MbhD-like_TM.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF13244; DUF4040; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..800
FT /note="Putative antiporter subunit mnhA2"
FT /id="PRO_0000372299"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..615
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 800 AA; 89723 MW; 364F5DF955D9C479 CRC64;
MSLVYLMATN LLVMLIVLFT LSHRQLRKVA GYVALIAPIV TSTYFIMKIP DVIRNKFIAV
RLPWMPSIDI NLDLRLDGLS LMFGLIISLI GVGVFFYATQ YLSHSTDNLP RFFIYLLLFM
FSMIGIVIAN NTILMYVFWE LTSISSFLLI SYWYNNGESQ LGAIQSFMIT VFGGLALLTG
FIILYIITGT NTITDILNQR NAISRHPLFI PMILMLLLGA FTKSAQFPFH IWLPKAMAAP
TPVSAYLHSA TMVKAGIFLL FRFTPLLGLS NVYIYTVTFV GLITMLFGSL TALRQYDLKG
ILAYSTISQL GMIMTMVGLG GGYAQHTSDE LSKFYILVLF AGLFHLMNHA VFKCALFMGV
GIIDHESGTR DIRLLNGMRK VFPKMHIVML LAALSMAGVP FLNGFLSKEM FLDSLTKANE
LDQYGFVLTF VIISIGVIAS ILTFTYALYM IKETFWGNYN IEKFKRKQIH EPWLFSLPAV
ILMLLIPVIF FVPNVFGNFV ILPATRSVSG IGAEVDAFVP HISQWHGVNL PLILSIVVII
IGLILALVVN WKEVTHQIIK SASITDGYRK IYREFELYSA RGIRALMNNK LNYYIMITLF
IFVAIVVYGY LTVGFPHVHQ LHISSFGPLE VILSVVTLII GISLIFIRQR LTMVVLNGMI
GFAVTLYFIA MKAPDLALTQ LVVETITTIL FIVSFSRLPN IPRVKANLKK ETFKIIVSLV
MALTVVSLIF VAQQADGMPS IAKFYEDAYE LTGGKNIVNA ILGDFRALDT MFEGLVLIIA
GLGIYTLLNY KDRRGQDERE
