MNHA2_STAHJ
ID MNHA2_STAHJ Reviewed; 800 AA.
AC Q4L443;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Putative antiporter subunit mnhA2;
DE AltName: Full=Mrp complex subunit A2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SH2275;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; AP006716; BAE05584.1; -; Genomic_DNA.
DR RefSeq; WP_011276534.1; NC_007168.1.
DR AlphaFoldDB; Q4L443; -.
DR SMR; Q4L443; -.
DR STRING; 279808.SH2275; -.
DR EnsemblBacteria; BAE05584; BAE05584; SH2275.
DR KEGG; sha:SH2275; -.
DR eggNOG; COG1009; Bacteria.
DR eggNOG; COG2111; Bacteria.
DR HOGENOM; CLU_007100_2_1_9; -.
DR OMA; LSFTQFM; -.
DR OrthoDB; 1274678at2; -.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MbhD-like_TM.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF13244; DUF4040; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..800
FT /note="Putative antiporter subunit mnhA2"
FT /id="PRO_0000372300"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 800 AA; 89141 MW; 56E128345D7C92F6 CRC64;
MSLVYLLGGL IVIMLIVLMT LFIKSLRRFA GYIALLAPIL ASGYFLAQIP NVLHGKFVEF
KIPWMPAIDV NLDFRLDGLG LMFGLIISII GVAVFFYATQ YLSVNRDNLP RFFLYLLLFM
FSMLGIVVSN NTILMYVFWE LTSVSSFLLI SYWYSNAESQ LGAIQSFIIT VLGGLALLTG
FIMLYIITGT NTISELLTQS HSISEHALFI PMMIMLLIGA FTKSAQFPFH IWLPKAMAAP
TPVSAYLHSA TMVKAGIFLL FKFTPILGLS DSYIYIVTFV GLITMIFGSV TALRQYDLKG
ILAYSTISQL GMIMSMVGLG GGIAQHSSGP MAETYTLILF AGLFHLMNHA IFKCALFMGV
GIIDHEAGTR DIRRLSGMRK FFPKMNLVMT LAALSMAGVP LLNGFLSKEM FFDSLVSAIE
LQQFGLTLTI IVVAIGVIAS IFTFVYAVYM LKETYWGEFD EKKVPKKHIH EPWLFSLPAI
ILMVMIPIIF FIPNFFTEHL VLPALRNVTN LGSSVDAIAP HVSQWHGVNL PLIFSVIVII
VGLILALKVN WKAITHQVIK YASITNSYRN VYRGFERYSG QMIRGLMNNR LNHYNIITVL
IFSILIAYGI FQVGLPKLHQ IEVSEFGPLE VILGIMISVV GIALVFIRQR LTMVILNGII
GYSVALFFLL MRAPDLALTQ LVVETITTIL FIVSFSRLPN IARTTANMKK ETIKIIVSFI
MAGAVVTLIF IAQQGDGLES ISKYYTNAYE LTGGKNIVNA ILGDFRALDT MFEGIVLIIA
GLGIYTLLHY KDRRGQDERK
