MNHA2_STAS1
ID MNHA2_STAS1 Reviewed; 798 AA.
AC Q49VG9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Putative antiporter subunit mnhA2;
DE AltName: Full=Mrp complex subunit A2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SSP2096;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; AP008934; BAE19241.1; -; Genomic_DNA.
DR RefSeq; WP_011303738.1; NZ_MTGA01000039.1.
DR AlphaFoldDB; Q49VG9; -.
DR SMR; Q49VG9; -.
DR STRING; 342451.SSP2096; -.
DR EnsemblBacteria; BAE19241; BAE19241; SSP2096.
DR KEGG; ssp:SSP2096; -.
DR PATRIC; fig|342451.11.peg.2089; -.
DR eggNOG; COG1009; Bacteria.
DR eggNOG; COG2111; Bacteria.
DR HOGENOM; CLU_007100_2_0_9; -.
DR OMA; LSFTQFM; -.
DR OrthoDB; 1274678at2; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MbhD-like_TM.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF13244; DUF4040; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..798
FT /note="Putative antiporter subunit mnhA2"
FT /id="PRO_0000372301"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 674..694
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 710..730
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 766..786
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 798 AA; 89207 MW; EA8723AC6B6E78F6 CRC64;
MSLVYLLSTL ILIMVILLFT LTNIKFQKYA GHIALLAPIV ASVYFLYQLP SVMQGNFVSV
KIPWLTLLDI NIDFRLDGLS LFFSLLISLI GLAVVYYATQ YLSKEHDNLP RFYVYLLLFM
FSMLGIVTAN NTILMYVFWE LTSVSSFLLI VYWYSKGDSQ FGAIQSFMIT VFGGLALLAG
FIMIYIVTGT NSITSIIEQS DKIAQSHLFI PIIILLLLGA FTKSAQFPFH IWLPKAMAAP
TPVSAYLHSA TMVKAGIFLL FRFTSVLGLS DFYIYSVTFV GLITMIFGAV NATRQFDMKA
ILAYSTISQL GMIVSMVGLG GGFAQHPTGE LSKIYGMILF AALFHLMNHA LYKGALFMGV
GIIDHETGTR DIRRLSGLKK VFPITHIVML LSALSMAGIP FLNGFLSKEM FFDGLVSTVE
LPQFNLTLTV IITVIGVIAS IFTLVYGVYM IKEVFWGDYQ QADLPKKSPH EPFLFTLPSA
IMMILLPVIF FIPNLFGHNI ILPALRSITI GEKVDQVAPH VSQWHGFNLP LILSLIVIVV
GFIMALRINW KKYANQVKVK TITDLYLGSY KQFEHYSGYG IRSLMNNRLN HYITITLLIF
SMVVIYGMIQ AGFPEVHQIH VSDFGPIEVI TLIVVFVLGI ALTFIRQRLT MVVLNGIIGY
CVTIFFILMK APDLALTQLV VETITTILFI VSFSRLPNVP RAKVNKKREA VKIIVSLLMA
VIVVTLVFIA QQGDSMPTIS TFYHDAYKLT GGKNIVNAIL GDFRAIDTLF EGMVLIIAGL
GIYTLLNFKE RRGQDERE
