ID   MNHB1_STAAT             Reviewed;         142 AA.
AC   A8Z058;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Na(+)/H(+) antiporter subunit B1;
DE   AltName: Full=Mnh complex subunit B1;
GN   Name=mnhB1; OrderedLocusNames=USA300HOU_0911;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA   Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA   Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA   Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA   Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000730; ABX28932.1; -; Genomic_DNA.
DR   RefSeq; WP_001081626.1; NC_010079.1.
DR   AlphaFoldDB; A8Z058; -.
DR   SMR; A8Z058; -.
DR   GeneID; 66839149; -.
DR   KEGG; sax:USA300HOU_0911; -.
DR   HOGENOM; CLU_101659_1_1_9; -.
DR   OMA; HPGFLMP; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005281; CPA3_sub_B.
DR   InterPro; IPR007182; MnhB.
DR   Pfam; PF04039; MnhB; 1.
DR   TIGRFAMs; TIGR00943; 2a6301s02; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..142
FT                   /note="Na(+)/H(+) antiporter subunit B1"
FT                   /id="PRO_0000372111"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   142 AA;  15682 MW;  4BF779759F08D24B CRC64;
     MNRQQNDLIL QFAAVIIFFM VMVFGFSLFL AGHYTPGGGF VGGLLFASSL VIITIAFDIE
     TMRKIFPLDF KILIGIGLVF CIATPIASWF LGKNFFTHVT FDIPLFILEP VHMTTAVFFD
     FGVLCAVVGT VMTIIISIGE NE