MNHB1_STAEQ
ID MNHB1_STAEQ Reviewed; 142 AA.
AC Q5HQL1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Na(+)/H(+) antiporter subunit B1;
DE AltName: Full=Mnh complex subunit B1;
GN Name=mnhB1; OrderedLocusNames=SERP0537;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000250}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B
CC family. {ECO:0000305}.
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DR EMBL; CP000029; AAW53940.1; -; Genomic_DNA.
DR RefSeq; WP_001831999.1; NC_002976.3.
DR AlphaFoldDB; Q5HQL1; -.
DR SMR; Q5HQL1; -.
DR STRING; 176279.SERP0537; -.
DR EnsemblBacteria; AAW53940; AAW53940; SERP0537.
DR GeneID; 50019208; -.
DR KEGG; ser:SERP0537; -.
DR eggNOG; COG2111; Bacteria.
DR HOGENOM; CLU_101659_1_1_9; -.
DR OMA; HPGFLMP; -.
DR OrthoDB; 1962104at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR005281; CPA3_sub_B.
DR InterPro; IPR007182; MnhB.
DR Pfam; PF04039; MnhB; 1.
DR TIGRFAMs; TIGR00943; 2a6301s02; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..142
FT /note="Na(+)/H(+) antiporter subunit B1"
FT /id="PRO_0000372114"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 142 AA; 15790 MW; 3467B43DCFA29EAF CRC64;
MNRQQNNLIF QYAAVIIFFM VIVFGFSLFL AGHYTPGGGF VGGLLFASAL LVITIAYDVK
TMRKIFPLDF KILIGIGLLF CVGTPLTSWF MSKNFFTHVT FDIPLPLLEP MHMTTAMFFD
FGVLCAVVGT IMTIIISIGE NE
